131184-64-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol is used as a pharmacological agent for its ability to inhibit the reuptake of serotonin and norepinephrine. This property makes it a candidate for the treatment of various medical conditions such as depression and anxiety disorders. Its effectiveness in these areas is still under investigation, and further research is required to establish its safety and efficacy.
Used in Research and Development:
In the realm of scientific research, 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol serves as a valuable compound for exploring new avenues in the treatment of mood and anxiety-related disorders. Its study contributes to the broader understanding of neurotransmitter reuptake inhibition and its impact on mental health conditions.

InChI:InChI=1/C27H32N2O4/c30-22(18-31-25-11-5-7-20-6-1-2-8-24(20)25)16-28-21-12-14-29(15-13-21)17-23-19-32-26-9-3-4-10-27(26)33-23/h1-11,21-23,28,30H,12-19H2

Upstream product

• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 89483-72-7 1-(2-benzodioxanylmethyl)-4-piperidylamine 
• 131184-67-3 1-(2-benzodioxanylcarbonyl)-4,4-ethylenedioxypiperdine 
• 89483-71-6 1-(2-benzodioxanylmethyl)-4-hydroximino-piperidine 
• 131184-65-1 4,4-ethylenedioxy-1-(phenoxycarbonyl)piperidine 
• 37943-54-7 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 3663-81-8 1,4-benzodioxan-2-carbonyl chloride 
• 53491-25-1 1-(2-benzodioxanylmethyl)-4-piperidone 
• 41979-37-7 4-oxo-piperidine-1-carboxylic acid phenyl ester 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 53491-24-0 8-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane 

Relevant academic research and scientific papers

Synthesis of the new α- and β-adrenergic antagonist 1-[1-(2-benzodioxanylmethyl)-4-piperidyl]amino-3-(1-naphthoxy)-2- propanol

The synthesis and in vitro α- and β-adrenergic blocking potency of 1-[1-(2-benzodiaxanylmethyl)-4-piperidyl]amino-3-(1-naphthoxy)-2- propanol (I) are described. Thus, N-benzyl-4piperidone was protected and debenzylated to the carbamate (V), which upon alkaline hydrolysis and acylation gave benzodioxanic amide (IX). Reduction of the amide group, deprotection of the ketone function of (X), and reductive amination gave the 4-aminopiperidine (XIII), which was finally condensed with the appropriate epoxide to yield the aminopropanol (I). Compound (I) is formally derived from a combination of piperoxan (II) and propranolol (III), and was approximately 10 times less potent than each one of these drugs, as an α- and β-adrenergic blocker respectively.