37943-54-7

Basic information

• Product Name: 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane
• Synonyms: 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane;1,4-Dioxa-8-azaspiro[4.5]decane, 8-(phenylMethyl)-
• CAS NO: 37943-54-7
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.30616
• EINECS: 253-727-2
• Mol File: 37943-54-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 335.1°Cat760mmHg
• Flash Point: 120.4°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.000122mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane(37943-54-7)
• EPA Substance Registry System: 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane(37943-54-7)

Safety Data

• Hazardous Substances Data: 37943-54-7(Hazardous Substances Data)

Usage

General Description

8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane is a chemical compound with a unique spirocyclic structure that contains both oxygen and nitrogen atoms. It is a member of the spiroketals, which are known for their diverse biological activities. 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane has a benzyl group attached to the nitrogen atom, giving it potential for use as a pharmacological agent. The spirocyclic structure also imparts stability and rigidity to the molecule, making it a potential candidate for drug design and development. Due to its unique structure and potential therapeutic properties, 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane is an interesting target for further research in the field of medicinal chemistry.

InChI:InChI=1/C14H19NO2/c1-2-4-13(5-3-1)12-15-8-6-14(7-9-15)16-10-11-17-14/h1-5H,6-12H2

Upstream product

• 1233656-18-2 C₁₆H₁₉O₄P 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 84157-05-1 phenyl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone 
• 98-88-4 benzoyl chloride 
• 100-39-0 benzyl bromide 
• 20821-52-7 1-benzyl-4-piperidone hydrochloride 
• 107-21-1 ethylene glycol 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 40256-34-6 2-((1-benzyl-4-methylpiperidin-4-yl)oxy)ethanol 
• 40256-25-5 N-Benzyl-4-(2'-hydroxyethoxy)-piperidine 
• 40256-36-8 2-(1-benzyl-4-propyl-4-piperidyloxy)-ethanol 
• 40256-35-7 2-(1-benzyl-4-ethyl-4-piperidyloxy)-ethanol 
• 51787-82-7 8-[4,4-bis-(4-fluoro-phenyl)-butyl]-1,4-dioxa-8-aza-spiro[4.5]decane 
• 51787-84-9 4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone 
• 131184-64-0 1-<1-(2-benzodioxanylmethyl)-4-piperidyl>amino-3-(1-naphthoxy)-2-propanol 
• 174643-75-5 4-[2-(Diphenylmethoxy)ethyl]-1-(phenylmethyl)piperidine 
• 76876-70-5 N-benzyl-4-(2-hydroxyethyl)piperidine 
• 40110-55-2 ethyl 2-(1-benzylpiperidine-4-ylidene)acetate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 51787-77-0 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ethyl ester 

Relevant articles and documents

IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Disclosed are compounds of Formula (I), including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

Structure-activity relationship studies of novel 4-[2-[bis(4- fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: Synthesis and biological evaluation at the dopamine and serotonin transporter sites

Several analogs of the potent dopamine (DA) transporter ligand 4-[2- [bis(4-fluorophenyl)-methoxy]ethyl]-1-(3-phenylpropyl)piperidine, 1b, were made and biologically evaluated for their binding at the DA and serotonin (5HT) transporters in rat striatal membranes. Different alkyl chain lengths and substitutions were introduced in these molecules to generate an optimum activity and selectivity for the DA transporter. In general, unsubstituted and fluoro-substituted compounds were the most active and selective for the DA transporter. The compound 4-[2(diphenylmethoxy)ethyl]-1-benzylpiperidine, 9a, showed high potency and was the most selective for the DA transporter (5HT/DA = 49) in this series of compounds. Some of these novel analogs were found to be more selective in binding at the DA transporter than the original GBR 12909 molecule, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl)piperidine.