13119-19-2Relevant academic research and scientific papers
Role of Phosphine Sterics in Strained Aminophosphine Chelate Formation
Bowes, Eric G.,Dawson Beattie,Love, Jennifer A.
, p. 2925 - 2929 (2019/03/02)
The preparation of four-membered aminophosphine (PN) chelates from common metal precursors has largely evaded realization because of the ring strain associated with these species. We report a straightforward approach to the synthesis of such PN metallacycles using simple α-PN ligands analogous to the popular class of small-bite-angle diphosphinomethane ligands. It is demonstrated that bulky phosphine substituents are important to the formation of these chelates.
Triethylsiloxymethyl-N,N-dimethylamine, Et3SiOCH2NMe2: A Dimethylaminomethylation (Mannich) Reagent for O–H, S–H, P–H and Aromatic C–H Systems
Gonzalez, Paulina E.,Sharma, Hemant K.,Chakrabarty, Sanchita,Metta-Maga?a, Alejandro,Pannell, Keith H.
, p. 5610 - 5616 (2017/10/13)
Triethylsiloxymethylamine, Et3SiOCH2NMe2, readily synthesized in high yield by the hydrosilylation reaction between Et3SiH and DMF, is an excellent (N,N-dimethylamino)methyl transfer agent to a representative range of aliphatic alcohols, thiols, and Ph2PH (E–H) materials. The reactions are almost instantaneous at room temperature in inert solvents and require no activating agents to produce E–CH2NMe2 products in high yields and illustrate the title compound as an excellent addition to the family of organic reagents. For aromatic alcohols, electrophilic substitution of the aromatic ring occurs in high yield. Crystal structures of new materials such as the cholestero–CH2NMe2 derivative, 2–4-[bis(N,N-dimethylamino)methyl]-1-naphthol, and the phosphine oxide derived from Ph2PCH2NMe2 are reported.
Role of Through Space 2p-3d Overlap in the Alkylation of (ω-N,N-Dimethylaminoalkyl)diphenylphosphines and in the Alkaline Decomposition of Related Quaternary Phosphonium Salts
McEwen, William E.,Smith, Joanne H.,Woo, Edward J.
, p. 2746 - 2751 (2007/10/02)
A series of (ω-N.N-dimethylaminoalkyl)diphenylphosphines has been prepared and subjected to reaction with benzyl chloride in benzene-methanol (60:40 v/v) at 31.0 +/- 0.1 deg C.Each of quaternization reactions was found to follow the second-order rate law,
