1312027-77-2Relevant academic research and scientific papers
Synthesis of some new quinolino pyrimidines and isoxazoles and evaluation of their antimicrobial activity
Mistry,Desai,Patel
, p. 261 - 264 (2013/09/24)
4-(2′-Chloro-6′-methyl (3′-quinolyl)-6- (substitutedphenyl)-3,4,5-trihydropyrimidin-2-ones (3a-j), 4-(2′-chloro- 6′-methyl (3′-quinolyl))-6-(substitutedphenyl)-3,4,5- trihydropyrimidin-2-thiones (4a-j) and 5-(2′-chloro-6'-methyl (3′-quinolyl))-3-(substitutedphenyl) isoxazoles (5a-j), have been synthesized by the reaction of 3-(2-chloro-6-methyl (6-quinolyl))-1- (substitutedphenyl) prop-2-ene-1-ones (2a-j) with urea, thiourea and hydroxyl amine hydrochloride respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of the synthesized compounds have been established on the basis of elemental analysis, IR and 1H NMR spectral data.
