335398-84-0Relevant academic research and scientific papers
A facile regio- and stereoselective synthesis of novel spiro[indolin-3,2′-pyrrolidin]-2-one’s via 1,3-dipolar cycloaddition of azomethine ylides
Saravana Mani, Kailasam,Rajendran, Subramaniam Parameswaran
, p. 1324 - 1330 (2018)
A facile regio and stereoselective synthesis of novel spiro[indolin-3,2′-pyrrolidin]-2-one’s have been accomplished through 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reaction of isatin and benzyl amine with quinoline bearing dipolarophiles in good yields. The synthesized compounds were well characterized through different spectroscopic techniques, such as single crystal XRD, FTIR, NMR, and mass spectral analysis.
A facile atom economic one pot multicomponent synthesis of bioactive spiro-indenoquinoxaline pyrrolizines as potent antioxidants and anti-cancer agents
Saravana Mani, Kailasam,Kaminsky, Werner,Rajendran, Subramaniam Parameswaran
, p. 301 - 310 (2017/12/28)
A competent and highly discriminating one-pot method for the synthesis of biologically active novel spiro-indenoquinoxaline pyrrolizines accumulating three pharmocophoric cores, heterocyclic quinoline scaffold, pyrrolizines and indeno-quinoxaline, in a single molecular framework by means of a four-component reaction between ninhydrin, o-phenylenediamine, l-proline and quinolinyl chalcones in methanol via [3+2] cycloaddition was developed. The structures of the compounds were well characterized by FT-IR, NMR, ESI-MS, XRD and elemental analysis. The synthesized compounds were screened for in vitro antioxidant activity using DPPH, nitric oxide, super oxide radical and in vitro cytotoxic activity against MCF-7 and A-549 cancer cell lines and visualized using the fluorescent microscopic technique. The newly synthesized compounds exhibited excellent antioxidant activity compared to the standard molecule, i.e., BHT. In terms of cytotoxic activity, compounds 5c, 5e, 6c and 6e were found to exhibit significant activity, when compared to standard doxorubicin against MCF-7 and A-549 cancer cells using the MTT assay method. The cell morphology analysis clearly indicates cell death was induced by apoptosis and necrosis pathways. Molecular docking studies were performed using an EGFR inhibitor to determine the molecular interactions between the compounds and proteins.
Synthesis of new quinoline-2-pyrazoline-based thiazolinone derivatives as potential antimicrobial agents
Desai,Joshi,Rajpara
, p. 3663 - 3674 (2013/07/26)
A series of 2-(5-(2-chloro-6-methylquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H- pyrazol-1-yl)thiazol-4(5H)ones (4a-l) were synthesized and characterized by IR, 1H NMR, 13C NMR, and mass spectra. All the synthesized compounds were tested for their in vitro antimicrobial activity against Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), and Aspergillus clavatus (MTCC 1323) by serial broth dilution. Compounds 4e, 4f, 4g, 4i, 4j, and 4l were the most distinctive derivatives identified in present study because of their remarkable in vitro antimicrobial potency.
Conventional and microwave-assisted synthesis of pyrazole derivatives and screening of their antibacterial and antifungal activities
Mistry,Desai,Patel,Patel
experimental part, p. 746 - 751 (2012/07/27)
5-{2'-Chloro-6'-methyl-(3'-quinolyl)}-3-(substitutedphenyl) pyrazole 3a-j, 5-{2'-chloro-6'-methyl-(3'-quinolyl)}-3- (substitutedphenyl) pyrazole carboxamide 4a-j and 5-{2'-chloro-6'-methyl-(3'-quinolyl)}-3-(substitutedphenyl) pyrazole carbothiamide 5a-j have been synthesized by the reaction of 3-(2'-chloro-6'-methyl(3'-quinolyl))-1-(substitutedphenyl)prop- 2-en-1-one 2a-j with hydrazine hydrate, semicarbazide hydrochloride and thiosemicarbazide hydrochloride respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
Synthesis of azetidinones and thiazolidinones and their antimicrobial screening
Mistry,Desai,Patel,Patel
, p. 157 - 162 (2013/09/24)
3-Chloro-1-[6'-{2"-chloro-6'-methyl-(3"-quinolyl) -4'-(substitutedphenyl)pyrimidin-2'-yl)}]-4-(2'"-chlorophenyl) azetidin-2-ones. 5a-j and 3-[6'-{2"-chloro-6"-methyl-(3"- quinolyl)}-4'-(substitutedphenyl)pyrimidin-2'-yl]-4-(2'"-chlorophenyl)-1, 3-thiazolidin-4-ones 6a-j have been synthesized by the reaction of 2-[1"-aza-2"-(2"'-chlorophenyl) vinyl]-6-[{2'-chloro-6'-methyl (3'-quinolyl)}]-4-(substitutedphenyl) pyrimidines 4a-j with chloroacetyl chloride and thioglycollic acid respectively. These compounds have been screened for their antimicrobial activities against different microorganisms. The structures of synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and Mass spectral data.
Synthesis of some new quinolino pyrimidines and isoxazoles and evaluation of their antimicrobial activity
Mistry,Desai,Patel
, p. 261 - 264 (2013/09/24)
4-(2′-Chloro-6′-methyl (3′-quinolyl)-6- (substitutedphenyl)-3,4,5-trihydropyrimidin-2-ones (3a-j), 4-(2′-chloro- 6′-methyl (3′-quinolyl))-6-(substitutedphenyl)-3,4,5- trihydropyrimidin-2-thiones (4a-j) and 5-(2′-chloro-6'-methyl (3′-quinolyl))-3-(substitutedphenyl) isoxazoles (5a-j), have been synthesized by the reaction of 3-(2-chloro-6-methyl (6-quinolyl))-1- (substitutedphenyl) prop-2-ene-1-ones (2a-j) with urea, thiourea and hydroxyl amine hydrochloride respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of the synthesized compounds have been established on the basis of elemental analysis, IR and 1H NMR spectral data.
