888325-30-2Relevant academic research and scientific papers
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites
Gemma, Sandra,Gabellieri, Emanuele,Huleatt, Paul,Fattorusso, Caterina,Borriello, Marianna,Catalanotti, Bruno,Butini, Stefania,De Angelis, Meri,Novellino, Ettore,Nacci, Vito,Belinskaya, Tatyana,Saxena, Ashima,Campiani, Giuseppe
, p. 3421 - 3425 (2007/10/03)
We describe herein the development of novel huperzine A-tacrine hybrids characterized by 3-methylbicyclo-[3.3.1]non-3-ene scaffolds. These compounds were specifically designed to establish tight interactions, through different binding modes, with the midg
