131229-60-2

Usage

Uses

Used in Pharmaceutical and Cosmetic Industries:
[butoxy-(4-methoxybenzoyl)amino] acetate is used as an active ingredient for its antiseptic, anti-inflammatory, and antimicrobial properties, which contribute to the treatment of skin conditions such as acne, eczema, and psoriasis.
Used in Skincare Products:
In creams, lotions, and ointments, [butoxy-(4-methoxybenzoyl)amino] acetate is used as a therapeutic agent to help treat and alleviate symptoms of various skin conditions.
Used as a Preservative in Cosmetic Formulations:
[butoxy-(4-methoxybenzoyl)amino] acetate is used as a preservative to prevent the growth of harmful bacteria and fungi, ensuring the safety and longevity of cosmetic products.
Used in Sunscreens and UV Protection Products:
Due to its ability to absorb and filter UV radiation, [butoxy-(4-methoxybenzoyl)amino] acetate is used as an ingredient in sunscreens and other UV protection products to provide protection against the harmful effects of ultraviolet rays.

InChI:InChI=1/C14H19NO5/c1-4-5-10-19-15(20-11(2)16)14(17)12-6-8-13(18-3)9-7-12/h6-9H,4-5,10H2,1-3H3

Upstream product

• 106274-43-5 butyl p-methoxybenzohydroxamate 
• 57139-22-7 potassium p-methoxylbenzohydroxamate 
• 94-30-4 ethyl 4-methoxybenzoate 
• 563-63-3 silver(I) acetate 
• 139259-80-6 butyl N-chloro-p-methoxybenzohydroxamate 

Downstream Products

• 6946-35-6 butyl 4-methoxybenzoate 
• 64-19-7 acetic acid 
• 5579-27-1 1,4-dimethyl-1,4-diphenyl-2-tetrazine 

Relevant academic research and scientific papers

Solvolysis and mutagenesis of n-acetoxy-n-alkoxybenzamides - Evidence for nitrenium ion formation

Mutagenic N-acetoxy-N-butoxybenzamides undergo acid catalysed solvolysis in acetonitrile/water. Kinetic data and a Hammett σ+ correlation (ρ=-1.4) indicate nitrenium ion formation in the rate determining step. Levels of mutagenicity mirror the rates of solvolysis suggesting nitrenium ion involvement.

Evidence for the Formation of Nitrenium Ions in the Acid-catalysed Solvolysis of Mutagenic N-Acetoxy-N-Alkoxybenzamides

In aqueous acetonitrile, N-acetoxy-N-alkoxybenzamides undergo acid-catalysed solvolysis by the AAl1 mechanism to give acetic acid and nitrenium ions.This is indicated by an inverse dependence of the acid-independent rate constant, kH, upon the activity of water, a solvent kinetic isotope effect of 0.44 and positive Σ(excit.) values.In addition, relief of steric compression at the nitrogen enhances the rate of solvolysis.Hammett correlations with ?+ substituent constants were found for the rates of solvolysis of para-substituted-N-acetoxy-N-butoxybenzamides and N-acetoxy-N-(para-substituted benzyloxy) benzamides.This fact and the low ρ-values of -1.35 and -1.56, respectively, are indicative of a strong build-up of positive charge in the transition state which has both nitrenium ion and oxonium ion character and is in accordance with computed molecular-orbital properties of N-alkoxynitrenium ions.Greater levels of mutagenicity have been measured for those compounds which are more readily solvolysed to nitrenium ions.