1312309-62-8

Basic information

• Product Name: Mes-PEG2-acid t-butyl ester
• Synonyms: Mes-PEG2-acid t-butyl ester;Ms-PEG2-t-butyl ester
• CAS NO: 1312309-62-8
• Molecular Formula: C12H24O7S
• Molecular Weight: 312.37976
• Mol File: 1312309-62-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 429.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.155±0.06 g/cm3(Predicted)
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: Mes-PEG2-acid t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Mes-PEG2-acid t-butyl ester(1312309-62-8)
• EPA Substance Registry System: Mes-PEG2-acid t-butyl ester(1312309-62-8)

Safety Data

• Hazardous Substances Data: 1312309-62-8(Hazardous Substances Data)

Usage

Description

Ms-PEG2-t-butyl ester is a PEG linker containing a mesyl group and a t-butyl protecting group. The mesyl group is a good leaving group for nucleophilic substitution reactions. The t-butyl is an acid labile protecting group. Upon removal, the carboxylic acid can react with primary amines. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 133803-81-3 2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate 
• 1663-39-4 tert-Butyl acrylate 

Downstream Products

• 1271728-79-0 tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate 
• 1312309-63-9 3-(2-(2-azidoethoxy)ethoxy)propanoic acid 
• 1610796-02-5 2,5-dioxopyrrolidin-1-yl-3 (2-(2-azidoethoxy)ethoxy)propanoate 
• 1938057-43-2 tert-butyl 3-(2-(2-iodoethoxy)ethoxy)propanoate 

Relevant articles and documents

NOVEL CONNECTED BODY AND USE THEREOF IN SPECIFIC CONJUGATION BETWEEN BIOMOLECULE AND DRUG

PROBLEM TO BE SOLVED: To provide: a method for producing a connected body; a method for using the connected body in the production of a uniform conjugate; and a method for applying the conjugate in the treatment of cancer, infectious diseases, and autoimmune diseases. SOLUTION: A novel connected body is provided that includes a 2,3-di-substituted succinic acid group or a 2-mono-substituted or 2,3-di-substituted fumaric acid or maleic acid (trans (E)- or cis (Z)-butenedioic acid) group for conjugating 2 or more compounds/cytotoxic agents per connected body with a cell-binding molecule by specifically bridge-linking to a pair of thiol on the cell-binding molecule. The connected body is exemplified by the following general formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of c-Met and/or p38 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.