133803-81-3

Basic information

• Product Name: Hydroxy-PEG3-t-butylester
• Synonyms: Hydroxy-PEG3-t-butylester;Hydroxy-PEG2-t-butyl ester;Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester;HO-PEG2-CH2CH2COOtBu;OH-PEG2-CH2CH2COOtBu;HO-PEG2-t-Butyl ester
• CAS NO: 133803-81-3
• Molecular Formula: C₁₁H₂₂O₅
• Molecular Weight: 234.29
• Mol File: 133803-81-3.mol

Chemical Properties

• Boiling Point: 321.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.046±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: Hydroxy-PEG3-t-butylester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxy-PEG3-t-butylester(133803-81-3)
• EPA Substance Registry System: Hydroxy-PEG3-t-butylester(133803-81-3)

Safety Data

• Hazardous Substances Data: 133803-81-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Hydroxy-PEG3-t-butylester is used as an ADC (Antibody Drug Conjugate) linker for the synthesis of antibody drug conjugates. This application takes advantage of its ability to connect antibodies with cytotoxic drugs, enhancing the targeting of cancer cells and improving the therapeutic index of the treatment.
Used in Chemical Synthesis:
Hydroxy-PEG3-t-butylester is used as a PROTAC (Proteolysis Targeting Chimera) linker for the synthesis of protein degradation inducers. Its role in this application is to connect a target protein ligand with an E3 ubiquitin ligase ligand, promoting the degradation of specific proteins and offering a new approach to treating various diseases, including cancer.
Used in Drug Delivery Systems:
Hydroxy-PEG3-t-butylester is used as a solubility enhancer in drug delivery systems due to its hydrophilic PEG spacer. This property can improve the pharmacokinetics and biodistribution of therapeutic agents, potentially reducing side effects and increasing the efficacy of the treatment.
Used in Bioconjugation:
Hydroxy-PEG3-t-butylester is used as a versatile building block in bioconjugation, allowing for the attachment of various biomolecules, such as peptides, proteins, or other functional groups, to create novel bioconjugates with tailored properties and applications in research and therapeutics.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 111-46-6 diethylene glycol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 1398044-50-2 C₁₁H₂₂O₄S 
• 1807503-92-9 3-[2-(2-bromoethoxy)ethoxy]propanoic acid 
• 1938057-43-2 tert-butyl 3-(2-(2-iodoethoxy)ethoxy)propanoate 
• 850090-13-0 9-(p-toluenesulfonyloxy)-3,6-diocanonanoic acid tert-butyl ester 

Relevant articles and documents

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