1312366-20-3

Basic information

• Product Name: (R)‐1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐ol
• Synonyms: (R)‐1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐ol
• CAS NO: 1312366-20-3
• Molecular Weight: 202.176
• Mol File: 1312366-20-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)‐1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)‐1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐ol(1312366-20-3)
• EPA Substance Registry System: (R)‐1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐ol(1312366-20-3)

Safety Data

• Hazardous Substances Data: 1312366-20-3(Hazardous Substances Data)

Upstream product

• 149946-79-2 1-(4'-(trifluoromethyl)phenyl)-allylalcohol 
• 14028-44-5 amoxapine 
• 97-72-3 2-Methylpropionic anhydride 
• 221527-77-1 (E)-1-(3-chloropropa-1-en-1-yl)-4-(trifluoromethyl)benzene 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 1826-67-1 vinyl magnesium bromide 

Relevant articles and documents

Method for preparing chiral gamma-amino alcohol and chiral alpha-allyl alcohol by one-pot method

The invention relates to a method for preparing chiral gamma-amino alcohol and chiral alpha-allyl alcohol by a one-pot method. The method comprises the following steps: making a racemic alpha-allyl alcohol compound, an amine compound, a chiral ruthenium complex and an alkaline reagent react in an organic solvent, and carrying out separation and purification after completion of the reaction, so that chiral gamma-aminoalcohols and chiral alpha-allylalcohol are prepared, wherein a chiral ruthenium complex is selected from one of them. According to the preparation method of the chiral compound, two chiral compounds with wide purposes, namely the chiral gamma-amino alcohol and the chiral alpha-allyl alcohol, are obtained at the same time through a one-pot reaction, the reaction is simple, the atom economy is high, few by-products are produced, and the requirements of green chemistry are met.

Isothiourea-Catalysed Acylative Kinetic Resolution of Aryl–Alkenyl (sp2vs. sp2) Substituted Secondary Alcohols

The non-enzymatic acylative kinetic resolution of challenging aryl–alkenyl (sp2vs. sp2) substituted secondary alcohols is described, with effective enantiodiscrimination achieved using the isothiourea organocatalyst HyperBTM (1 mol %) and isobutyric anhydride. The kinetic resolution of a wide range of aryl–alkenyl substituted alcohols has been evaluated, with either electron-rich or naphthyl aryl substituents in combination with an unsubstituted vinyl substituent providing the highest selectivity (S=2–1980). The use of this protocol for the gram-scale (2.5 g) kinetic resolution of a model aryl–vinyl (sp2vs. sp2) substituted secondary alcohol is demonstrated, giving access to >1 g of each of the product enantiomers both in 99:1 e.r.