1312442-41-3

Upstream product

• 41661-47-6 piperidin-4-one 
• 162269-90-1 3-bromo-4-(methoxymethoxy)benzaldehyde 

Downstream Products

• 1312442-47-9 C₃₁H₃₁Br₂NO₅ 
• 1312442-59-3 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(3-methylbenzyl)piperidin-4-one 
• 1312442-68-4 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(3-phenylpropyl)piperidin-4-one 
• 1312442-56-0 C₃₂H₃₃Br₂NO₅ 
• 1312442-52-6 C₃₁H₃₁Br₂NO₆ 
• 1312442-64-0 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(2-methoxybenzyl)piperidin-4-one 
• 1312442-49-1 C₃₀H₂₈Br₂ClNO₅ 
• 1312442-61-7 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(2-chlorobenzyl)piperidin-4-one 
• 1312442-54-8 C₃₁H₃₁Br₂NO₆ 
• 1312442-66-2 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(4-methoxybenzyl)piperidin-4-one 
• 1312442-48-0 C₃₁H₃₁Br₂NO₅ 
• 1312442-60-6 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-(4-methylbenzyl)piperidin-4-one 
• 1312442-67-3 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-phenethylpiperidin-4-one 
• 1312442-55-9 C₃₁H₃₁Br₂NO₅ 

Relevant academic research and scientific papers

Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity

Coactivator-associated arginine methyltransferase 1 (CARM1) represents a valuable target for hormone-dependent tumors such as prostate and breast cancers. Here we report the enzyme and cellular characterization of the 1-benzyl-3,5-bis(3-bromo-4-hydroxybenzylidene)piperidin-4-one (7g) and its analogues 8a-l. Among them, 7g, 8e, and 8l displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.