1312445-63-8 Usage
General Description
NVP-BKM120 (Hydrochloride) is a potent and selective inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) with potential antineoplastic activity. NVP-BKM120 (Hydrochloride) targets and inhibits the activity of the PI3K signaling pathway, which plays a key role in cell growth, survival, and metabolism. By blocking this pathway, NVP-BKM120 (Hydrochloride) may inhibit the growth and proliferation of cancer cells, making it a promising candidate for the treatment of various types of cancer. Additionally, it has been shown to exhibit good blood-brain barrier penetration, making it a potential candidate for the treatment of brain tumors. Preclinical studies have demonstrated its efficacy in a variety of cancer models, and it is currently being evaluated in clinical trials for its potential in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 1312445-63-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,2,4,4 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1312445-63:
(9*1)+(8*3)+(7*1)+(6*2)+(5*4)+(4*4)+(3*5)+(2*6)+(1*3)=118
118 % 10 = 8
So 1312445-63-8 is a valid CAS Registry Number.
1312445-63-8Relevant articles and documents
MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES
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, (2012/04/17)
The invention relates to processes for manufacturing a compound of formula (5) or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
