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CAS

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1312467-80-3

methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1312467-80-3 Structure

  • Basic information

    1. Product Name: methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate
    2. Synonyms: methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate
    3. CAS NO:1312467-80-3
    4. Molecular Formula:
    5. Molecular Weight: 608.816
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1312467-80-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate(1312467-80-3)
    11. EPA Substance Registry System: methyl 3-oxo-7α-benzoyloxy-12α-O-[2’(S)]tetrahydropyranyloxy-5β-cholan-24-oate(1312467-80-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1312467-80-3(Hazardous Substances Data)

1312467-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1312467-80-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,2,4,6 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1312467-80:
(9*1)+(8*3)+(7*1)+(6*2)+(5*4)+(4*6)+(3*7)+(2*8)+(1*0)=133
133 % 10 = 3
So 1312467-80-3 is a valid CAS Registry Number.

1312467-80-3Downstream Products

1312467-80-3Relevant articles and documents

Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells

De Ravel, Marc Rolland,Alameh, Ghina,Melikian, Maxime,Mahiout, Zahia,Emptoz-Bonneton, Agnès,Matera, Eva-Laure,Lomberget, Thierry,Barret, Roland,Rocheblave, Luc,Walchshofer, Nadia,Beltran, Sonia,El Jawad, Lucienne,Mappus, Elisabeth,Grenot, Catherine,Pugeat, Michel,Dumontet, Charles,Le Borgne, Marc,Cuilleron, Claude Yves

, p. 1832 - 1845 (2015)

A simple route for improving the potency of progesterone as a modulator of P-gp-mediated multidrug resistance was established by esterification or etherification of hydroxylated 5α/β-pregnane-3,20-dione or 5β-cholan-3-one precursors. X-ray crystallography of representative 7α-, 11α-, and 17α-(2′R/S)-O-tetrahydropyranyl ether diastereoisomers revealed different combinations of axial-equatorial configurations of the anomeric oxygen. Substantial stimulation of accumulation and chemosensitization was observed on K562/R7 erythroleukemia cells resistant to doxorubicin, especially using 7α,11α-O-disubstituted derivatives of 5α/β-pregnane-3,20-dione, among which the 5β-H-7α-benzoyloxy-11α-(2′R)-O-tetrahydropyranyl ether 22a revealed promising properties (accumulation index 2.9, IC50 0.5 μM versus 1.2 and 10.6 μM for progesterone), slightly overcoming those of verapamil and cyclosporin A. Several 7α,12α-O-disubstituted derivatives of 5β-cholan-3-one proved even more active, especially the 7α-O-methoxymethyl-12α-benzoate 56 (accumulation index 3.8, IC50 0.2 μM). The panel of modulating effects from different O-substitutions at a same position suggests a structural influence of the substituent completing a simple protection against stimulating effects of hydroxyl groups on P-gp-mediated transport.

NEW STEROID INHIBITORS OF PGP FOR USE FOR INHIBITING MULTIDRUG RESISTANCE

-

, (2011/07/07)

The present invention relates to a compound of formula (I) for its use for reversing or inhibiting multidrug resistance.

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