1312581-04-6Relevant articles and documents
Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors – Part I
Barberis, Claude,Moorcroft, Neil,Arendt, Chris,Levit, Mikhail,Moreno-Mazza, Sandra,Batchelor, Joseph,Mechin, Ingrid,Majid, Tahir
, p. 4730 - 4734 (2017/09/27)
Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.
AZAINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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Page/Page column 56, (2011/07/07)
The disclosure relates generally to compounds that inhibit Pim kinases. Provided herein are N-substituted azaindoles, or pharmaceutically acceptable salts thereof, which are useful as selective inhibitors of Pim kinases. The disclosure also relates to pharmaceutical compositions comprising these compounds, processes for their preparation, and methods of using the same.