940948-29-8

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodois used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodois used as a key intermediate in the production of agrochemicals. Its versatile chemical properties enable the creation of novel compounds with potential applications in crop protection and pest control.
Used in Chemical Research:
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodoserves as a useful reagent in chemical research and organic synthesis. Its presence in various chemical reactions aids in the exploration of new synthetic pathways and the development of innovative chemical compounds.
Used in Organic Synthesis:
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodois utilized as a starting material in the synthesis of diverse organic compounds. Its unique structure and reactivity contribute to the formation of a wide array of chemical products with various applications in different industries.

InChI:InChI=1/C7H4ClIN2/c8-5-1-2-10-7-4(5)3-6(9)11-7/h1-3H,(H,10,11)

Upstream product

• 271-63-6 7-Azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 1312581-05-7 4-chloro-2-iodo-1-methoxymethyl-1H-pyrrolo[2,3-b]pyridine 
• 1312581-04-6 4-chloro-1-(methoxymethyl)-1H-pyrrolo[2,3-b]pyridine 
• 55052-28-3 4-chloro-7-azaindole 
• 940948-31-2 4-chloro-2-iodo-1-(2-iodobenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1312581-09-1 4-chloro-2-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1312581-10-4 4-[4-(4-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1312579-40-0 3-[4-chloro-1-methyl-2-(4-piperazin-1-yl-phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-N-(2-dimethylamino-ethyl)-benzamide 
• 1312581-11-5 4-[4-(4-chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases

Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors – Part I

Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.

AZAINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The disclosure relates generally to compounds that inhibit Pim kinases. Provided herein are N-substituted azaindoles, or pharmaceutically acceptable salts thereof, which are useful as selective inhibitors of Pim kinases. The disclosure also relates to pharmaceutical compositions comprising these compounds, processes for their preparation, and methods of using the same.

Pyrrolopyridine kinase inhibiting compounds

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least one of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Met, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.