13126-07-3

Basic information

• Product Name: Z-PHE-MET-OH
• Synonyms: carbobenzoxyphenylalanylmethionine;N-CARBOBENZOXY-L-PHENYLALANYL-L-METHIONINE;Z-L-PHENYLALANYL-L-METHIONINE;Z-PHE-MET-OH;N-cbz-phe-met;N-carbobenzyloxy-Phe-Met;2-[[2-(benzyloxycarbonylamino)-3-phenyl-propanoyl]amino]-4-(methylthio)butyric acid;4-methylsulfanyl-2-[[3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]butanoic acid
• CAS NO: 13126-07-3
• Molecular Formula: C₂₂H₂₆N₂O₅S
• Molecular Weight: 430.52
• Mol File: 13126-07-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 727°C at 760 mmHg
• Flash Point: 393.5°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 3.47E-22mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-PHE-MET-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-PHE-MET-OH(13126-07-3)
• EPA Substance Registry System: Z-PHE-MET-OH(13126-07-3)

Safety Data

• Hazardous Substances Data: 13126-07-3(Hazardous Substances Data)

Usage

General Description

Z-Phe-Met-OH is a chemical compound consisting of three amino acids: phenylalanine, methionine, and a hydroxyl group. It is a synthetic peptide that is commonly used in biochemical and pharmaceutical research. Z-Phe-Met-OH plays a role in studying the enzymatic activities of proteolytic enzymes and is used as a substrate in kinematic assays to measure the rate of enzymatic hydrolysis. Additionally, this chemical compound is utilized in the development and testing of new drug candidates for treating various diseases and disorders. Its role in biochemistry and pharmacology makes Z-Phe-Met-OH an important chemical for understanding and manipulating enzymatic processes in cells and tissues.

InChI:InChI=1/C22H26N2O5S/c1-30-13-12-18(21(26)27)23-20(25)19(14-16-8-4-2-5-9-16)24-22(28)29-15-17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3,(H,23,25)(H,24,28)(H,26,27)

Upstream product

• 63-68-3 L-methionine 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1161-13-3 N-Cbz-L-Phe 
• 10332-17-9 Met-OMe 
• 78816-88-3 (S)-methyl 2-(((S)-2-(benzyloxy)carbonylamino)-3-phenylpropanamido)-4-(methylthio)butanoate 

Downstream Products

• 928787-83-1 Cbz-L-Phe-L-Met-Bt 
• 1526934-37-1 C₂₂H₂₇N₃O₄S 
• 71450-10-7 benzyl N-((1S)-2-[(1S)-1-(aminocarbonyl)-3-(methylsulfanyl)propyl]amino-1-benzyl-2-oxoethyl)carbamate 
• 1449018-08-9 C₂₈H₃₆N₂O₅S 
• 94775-95-8 Z-Phe-Met-NH_.i-C₃H₇ 

Relevant articles and documents

Convenient green preparation of dipeptides using unprotected α-amino acids

Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine by an ecological and convenient method in which the protection of C-terminals is not needed.

Design and Synthesis of Enkephalin Analogues: Part I - Synthesis of Met-Enkephalin Alkylamides with Enhanced Analgesic Potency

Synthesis of a series of alkylamides of Met-enkephalin has been achieved employing the key intermediate Boc-Tyr-Gly-Gly-Phe-Met-ONBzl (IV), obtained from Met-ONBzl by treatment with appropiate Nα-Boc-amino acid-2,4,5-trichlorophenyl esters in a