1312684-51-7

Basic information

• Product Name: 1-(1-bromonaphthalen-2-yl)ethanol
• CAS NO: 1312684-51-7
• Molecular Weight: 251.123
• Mol File: 1312684-51-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(1-bromonaphthalen-2-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-bromonaphthalen-2-yl)ethanol(1312684-51-7)
• EPA Substance Registry System: 1-(1-bromonaphthalen-2-yl)ethanol(1312684-51-7)

Safety Data

• Hazardous Substances Data: 1312684-51-7(Hazardous Substances Data)

Upstream product

• 3378-82-3 1-bromo-2-naphthaldehyde 
• 676-58-4 methylmagnesium chloride 
• 108059-68-3 1-(1-bromonaphthalen-2-yl)ethan-1-one 
• 1312684-50-6 1-bromo-N-methoxy-N-methyl-2-naphthamide 
• 20717-79-7 1-bromo-2-naphthoic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1312684-54-0 2-(1-azidoethyl)-1-(3-fluorophenyl)naphthalene 
• 1312684-55-1 1-[1-(3-fluorophenyl)-2-naphthyl]ethanamine 
• 1312682-20-4 N-{1-[1-(3-fluorophenyl)-2-naphthyl]ethyl}-9H-purin-6-amine trifluoroacetate 

Relevant articles and documents

Phosphine- and water-promoted pentannulative aldol reaction

Herein, an efficient metal-free intramolecular aldol reaction for the synthesis of an unusual class of cyclopentanoids is described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realised to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism.

Copper-mediated/catalyzed oxyalkylation of alkenes with alkylnitriles

A copper-promoted oxyalkylation of alkenes with alkylnitriles has been developed. The protocol provides rapid access to phthalides (γ-lactones) or isochromanones (d-lactones) via the formation of a C(sp3)-C(sp3) and a C(sp3)-O bond with the generation of up to two quaternary carbon atoms. Mechanistic studies suggest that this reaction is initiated by the formation of the C(sp3)-C(sp3) bond rather than the C(sp3)-O bond. Catalytic conditions were subsequently developed using carboxylic acid as an internal nucleophile.