13127-77-0

Basic information

• Product Name: N,N-bis(2-hydroxyethyl)-p-chloroaniline
• Synonyms: N,N-bis(2-hydroxyethyl)-p-chloroaniline
• CAS NO: 13127-77-0
• Molecular Weight: 215.68
• Mol File: 13127-77-0.mol

Chemical Properties

• CAS DataBase Reference: N,N-bis(2-hydroxyethyl)-p-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-hydroxyethyl)-p-chloroaniline(13127-77-0)
• EPA Substance Registry System: N,N-bis(2-hydroxyethyl)-p-chloroaniline(13127-77-0)

Safety Data

• Hazardous Substances Data: 13127-77-0(Hazardous Substances Data)

Upstream product

• 75-21-8 oxirane 
• 106-47-8 4-chloro-aniline 
• 107-07-3 2-chloro-ethanol 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 6636-75-5 4-chloro-N,N-bis(2-chloroethyl)aniline 
• 64977-12-4 N,N-bis-(2-bromo-ethyl)-4-chloro-aniline 
• 86396-81-8 6-(p-chlorophenyl)-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocine 
• 106073-45-4 2-methyl-6-(p-chlorophenyl)-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocine 
• 1190861-65-4 2,2'-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl)dimethanesulfonate 
• 1428438-45-2 C₁₈H₁₆ClNO₄ 

Relevant articles and documents

Synthesis, crystal structure and biological activity of novel diester cyclophanes

A series of novel diester cyclophanes was synthesized by esterification of 1,2-benzenedicarbonyl chloride with eight different diols under high dilution conditions. The structures of the compounds were verified by elemental analysis, 1H nuclear magnetic resonance (NMR), IR spectroscopy and high resolution mass spectrometry (HRMS). The crystal structures of two compounds were characterized by single crystal X-ray diffractometry (XRD). All the new cyclophanes were evaluated for biological activities and the results showed that some of these compounds have low antibacterial or antifungal activities.

The reaction of primary aromatic amines with alkylene carbonates for the selective synthesis of bis-N-(2-hydroxy)alkylanilines: The catalytic effect of phosphonium-based ionic liquids

At T ≥ 140 °C, different primary aromatic amines (pX-C 6H4NH2; X = H, OCH3, CH3, Cl) react with both ethylene- and propylene-carbonates to yield a chemoselective N-alkylation process: bis-N-(2-hydroxyalkyl)anilines [pX-C 6H4N(CH2CH(R)OH)2; R = H, CH 3] are the major products and the competitive formation of carbamates is substantially ruled out. At 140 °C, under solventless conditions, the model reaction of aniline with ethylene carbonate goes to completion by simply mixing stoichiometric amounts of the reagents. However, a class of phosphonium ionic liquids (PILs) such as tetraalkylphosphonium halides and tosylates turn out to be active organocatalysts for both aniline and other primary aromatic amines. A kinetic analysis monitored by 13C NMR spectroscopy, shows that bromide exchanged PILs are the most efficient systems, able to impart a more than 8-fold acceleration to the reaction. The reactions of propylene carbonate take place at a higher temperature than those of ethylene carbonate, and only in the presence of PIL catalysts. A mechanism based on the Lewis acidity of tetraalkylphosphonium cations and the nucleophilicity of halide anions has been proposed to account for both the reaction chemoselectivity and the function of the catalysts.

New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

Synthesis of β-amino alcohols from aromatic amines and alkylene carbonates using Na-Y zeolite catalyst

A simple, efficient, and environmentally benign methodology for the synthesis of β-amino alcohols from aromatic amines and alkylene carbonates in the presence of the highly active and reusable solid base catalyst Na-Y zeolite is demonstrated. Georg Thieme Verlag Stuttgart.