N,N-bis(2-hydroxyethyl)-p-chloroaniline

Base Information

• Chemical Name: N,N-bis(2-hydroxyethyl)-p-chloroaniline
• CAS No.: 13127-77-0
• Molecular Formula: C₁₀H₁₄ClNO₂
• Molecular Weight: 215.68
• Mol file: 13127-77-0.mol

Synonyms:N,N-bis(2-hydroxyethyl)-p-chloroaniline

Chemical Property of N,N-bis(2-hydroxyethyl)-p-chloroaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-bis(2-hydroxyethyl)-p-chloroaniline

There total 4 articles about N,N-bis(2-hydroxyethyl)-p-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[1,3]-dioxolan-2-one (96-49-1) + 4-chloro-aniline (106-47-8) → 2-(4-chlorophenylamino)ethanol (2933-81-5) + N,N-bis(2-hydroxyethyl)-p-chloroaniline (13127-77-0)

Guidance literature:

With Na-Y zeolite; In Triethylene glycol dimethyl ether; for 12h; Heating;

DOI:10.1055/s-2006-939697

Reference yield: 74.0%

4-chloro-aniline (106-47-8) + 2-chloro-ethanol (107-07-3) → N,N-bis(2-hydroxyethyl)-p-chloroaniline (13127-77-0)

Guidance literature:

With calcium carbonate; In water; for 18h; Reflux;

Reference yield:

oxirane (75-21-8,99932-75-9) + 4-chloro-aniline (106-47-8) → N,N-bis(2-hydroxyethyl)-p-chloroaniline (13127-77-0)

Guidance literature:

at 150 ℃;

DOI:10.1039/jr9490000183

upstream raw materials:

oxirane

4-chloro-aniline

2-chloro-ethanol

[1,3]-dioxolan-2-one

Downstream raw materials:

6-(p-chlorophenyl)-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocine

C₁₈H₁₆ClNO₄

2,2'-(4-chlorophenylazanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

2-methyl-6-(p-chlorophenyl)-5,6,7,8-tetrahydro-4H-1,3,6-dioxazocine

Refernces

• 1、 Selva, Maurizio,Fabris, Massimo,Lucchini, Vittorio,Perosa, Alvise,Noe, Marco. "The reaction of primary aromatic amines with alkylene carbonates for the selective synthesis of bis-N-(2-hydroxy)alkylanilines: The catalytic effect of phosphonium-based ionic liquids". experimental part. p. 5187 - 5198. Retrieved 2010/12/25.
• 2、 Shivarkar, Anandkumar B.,Gupte, Sunil P.,Chaudhari, Raghunath V.. "Synthesis of β-amino alcohols from aromatic amines and alkylene carbonates using Na-Y zeolite catalyst". . p. 1374 - 1378. Retrieved 2007/10/03.