131270-84-3

Upstream product

• 110-91-8 morpholine 
• 131270-70-7 2-Cyano-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-3-(4-nitro-phenyl)-thiopropionamide 
• 131270-74-1 2-Cyano-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-3-(4-nitro-phenyl)-thiopropionamide; compound with morpholine 
• 93440-31-4 α-thiocarbamoyl-β-(4'-nitrophenyl)acrylonitrile 
• 68029-55-0 (E)-2-cyano-3-(4-nitrophenyl)prop-2-enethioamide 
• 126-81-8 dimedone 

Downstream Products

• 131270-85-4 7,7-Dimethyl-4-(4-nitro-phenyl)-5-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carbonitrile 

Relevant academic research and scientific papers

CONDENSED PYRIDINES. IX. SYNTHESIS AND PROPERTIES OF SUBSTITUTED 3-CYANO-5,6,7,8-TETRAHYDRO-2(1H)-QUINOLINETHIONES

The reaction of arylmethylenecyanothioacetamides with cyclohexanone or dimedone leads to the formation of 4-aryl-3-cyano-5,6,7,8-tetrahydro-2(1H)-quinolinethiones and 4-aryl-7,7-dimethyl-5-oxo-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethiones, respectively.Upon heating in DMSO, these products undergo dehydrogenation to give 5,6,7,8-tetrahydro-2(1H)-quinolinethiones.These 2(1H)-quinolinethiones are smoothly alkylated at the sulfur atom by allyl bromide and phenacyl bromide.These transformations were used in the synthesis of substituted thienoquinolines and thiazoloquinolinium salts.

CYCLIZATION REACTIONS OF NITRILES. XXVII. THE STRUCTURE AND CONFORMATIONALLY AMBIDENT HETEROCYCLIZATION OF SUBSTITUTED 2-(THIOCARBAMOYL-2-CYANOETHYL)-3-OXO-1-CYCLOHEXENOLATES

The reaction of arylmethylenecyanoacetamides with dimedone in the presence of bases proceeds with the formation of anti isomers of derivatives of ammonium 2-(2-thiocarbamoyl-2-cyanoethyl)-3-oxo-1-cyclohexen-1-olate.The ambident cyclization of these compou