1312716-53-2

Upstream product

• 1312716-40-7 (S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate 
• 1312716-45-2 (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate 
• 1312716-49-6 (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate 
• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 

Downstream Products

• 1312716-61-2 (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethanamine) 

Relevant academic research and scientific papers

Synthesis and asymmetric catalytic activity of (1S,1′S)-4,4′- biquinazoline-based primary amines

A series of (1S,1′S)-4,4′-biquinazoline-based primary amines were prepared from natural amino acids via a six-step reaction sequence of protection and condensation followed by key synthetic steps including chlorination, nickel(0)-mediated homocoupling, and deprotection. These novel amines were screened for the asymmetric ethylation of aryl aldehydes to yield alcohols with an (S)-configuration with enantiomeric excesses (ee) varying from 2% to 95%.