tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

Base Information

Chemical Name:tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate
CAS No.:1312716-53-2
Molecular Formula:C₄₂H₄₄N₆O₄
Molecular Weight:696.849
Hs Code.:

Synonyms:tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

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Chemical Property of tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

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Technology Process of tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

There total 7 articles about tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1312716-49-6
(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

: 1312716-57-6
(S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate

: 1312716-45-2
(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

: 1312716-53-2
tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

Guidance literature:: (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate; With nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; zinc; In tetrahydrofuran; at 70 ℃; for 12h; Inert atmosphere;

With ammonia; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.01.009

Reference yield:

: 1312716-40-7
(S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1312716-57-6
(S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate

: 1312716-53-2
tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 0.58 h / 0 - 20 °C

2.1: N,N-diethylaniline; trichlorophosphate / benzene / 0.5 h / 0 °C / Reflux; Inert atmosphere

3.1: nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; zinc / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; N,N-diethylaniline; sodium hydroxide; zinc; trichlorophosphate; In tetrahydrofuran; ethanol; water; benzene;
DOI:10.1016/j.tetasy.2011.01.009

Reference yield:

: 1312716-45-2
(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

: 1312716-57-6
(S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate

: 1312716-53-2
tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-diethylaniline; trichlorophosphate / benzene / 0.5 h / 0 °C / Reflux; Inert atmosphere

2.1: nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; zinc / tetrahydrofuran / 12 h / 70 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; N,N-diethylaniline; zinc; trichlorophosphate; In tetrahydrofuran; benzene;
DOI:10.1016/j.tetasy.2011.01.009