1312755-43-3

Basic information

• Product Name: 2-PyridinaMine, 5-broMo-3-(1-propyn-1-yl)-
• Synonyms: 2-PyridinaMine, 5-broMo-3-(1-propyn-1-yl)-;5-Bromo-3-(1-propyn-1-yl)-2-pyridinamine;5-bromo-3-prop-1-ynyl-pyridin-2-ylamine
• CAS NO: 1312755-43-3
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.05858
• Mol File: 1312755-43-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PyridinaMine, 5-broMo-3-(1-propyn-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PyridinaMine, 5-broMo-3-(1-propyn-1-yl)-(1312755-43-3)
• EPA Substance Registry System: 2-PyridinaMine, 5-broMo-3-(1-propyn-1-yl)-(1312755-43-3)

Safety Data

• Hazardous Substances Data: 1312755-43-3(Hazardous Substances Data)

Upstream product

• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 74-99-7 prop-1-yne 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 1111638-02-8 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1200130-70-6 9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-72-8 1-benzenesulfonyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-73-9 1-benzenesulfonyl-5-bromo-2-bromomethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-74-0 1-benzenesulfonyl-5-bromo-2-{[cyanomethyl-(toluene-4-sulfonyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-75-1 9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200132-31-5 9-benzenesulfonyl-3-bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1312755-44-4 9-benzenesulfonyl-3-bromo-5-chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-21-0 4-(9-benzenesulfonyl-3-bromo-6-cyano-9H-dipyrido[2,3-b;4',3'-d]pyrrol-5-yloxy)piperidine-1-carboxylic acid tert-butyl ester 
• 1312756-22-1 9-benzenesulfonyl-3-bromo-5-[1-(2,2-difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-23-2 9-benzenesulfonyl-5-[1-(2,2-difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-24-3 9-benzenesulfonyl-3-bromo-5-[1-(2-methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-25-4 9-benzenesulfonyl-5-[1-(2-methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-26-5 9-benzenesulfonyl-3-bromo-5-{1-[2-(tetrahydropyran-2-yloxy)-ethyl]-piperidin-4-yloxy}-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 

Relevant articles and documents

SUBSTITUTED (AZA)INDOLE DERIVATIVES

The invention relates to substituted (aza)indole derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of α7 nicotinic acetylcholine receptor activity in a mammalian subject. (I)

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.