1228551-75-4

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-2-Methyl-, Methyl ester
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-2-Methyl-, Methyl ester;5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester
• CAS NO: 1228551-75-4
• Molecular Formula: C₁₀H₉BrN₂O₂
• Molecular Weight: 269.09466
• Mol File: 1228551-75-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.626±0.06 g/cm3(Predicted)
• PKA: 11.91±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-2-Methyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-2-Methyl-, Methyl ester(1228551-75-4)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-2-Methyl-, Methyl ester(1228551-75-4)

Safety Data

• Hazardous Substances Data: 1228551-75-4(Hazardous Substances Data)

Usage

Molecular Weight

272.11 g/mol This is the mass of one mole of the compound, based on the atomic weights of the elements that make it up.

Structure

1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo-2-methyl-, methyl ester This is a description of the compound's structure, indicating the arrangement of atoms and the type of bonding.

Family

Pyridine carboxylic acid This indicates that the compound belongs to a specific group of related chemical compounds.

Derivative

Methyl ester of 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid This indicates that the compound is derived from another compound through a chemical modification.

Use

Organic synthesis and pharmaceutical research This indicates that the compound is used in the creation of new compounds and in the development of pharmaceuticals.

Applications

Development of drugs This indicates that the compound has potential applications in the creation of new drugs.

Biological Activities

Exhibits diverse biological activities and pharmacological properties This indicates that the compound has a range of effects on biological systems.

Importance

Important intermediate in medicinal chemistry This indicates that the compound is a valuable building block in the synthesis of other pharmaceutical compounds.

Upstream product

• 1312755-43-3 5-bromo-3-(prop-1-yn-1-yl)pyridin-2-amine 
• 67-56-1 methanol 
• 1111638-02-8 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 76-02-8 trifluoroacetyl chloride 
• 1072-97-5 5-bromo-2-pyridylamine 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 

Downstream Products

• 1200130-72-8 1-benzenesulfonyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-70-6 9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-73-9 1-benzenesulfonyl-5-bromo-2-bromomethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-74-0 1-benzenesulfonyl-5-bromo-2-{[cyanomethyl-(toluene-4-sulfonyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-75-1 9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200132-31-5 9-benzenesulfonyl-3-bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1312755-44-4 9-benzenesulfonyl-3-bromo-5-chloro-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-21-0 4-(9-benzenesulfonyl-3-bromo-6-cyano-9H-dipyrido[2,3-b;4',3'-d]pyrrol-5-yloxy)piperidine-1-carboxylic acid tert-butyl ester 
• 1312756-22-1 9-benzenesulfonyl-3-bromo-5-[1-(2,2-difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-23-2 9-benzenesulfonyl-5-[1-(2,2-difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-24-3 9-benzenesulfonyl-3-bromo-5-[1-(2-methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-25-4 9-benzenesulfonyl-5-[1-(2-methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-26-5 9-benzenesulfonyl-3-bromo-5-{1-[2-(tetrahydropyran-2-yloxy)-ethyl]-piperidin-4-yloxy}-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 
• 1312756-27-6 9-benzenesulfonyl-3-bromo-5-[1-(2-hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4',3'-d]pyrrole-6-carbonitrile 

Relevant articles and documents

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.