1312782-62-9Relevant articles and documents
Easy stereoselective synthesis of 5α-estrane-3β,17α-diol, the major metabolite of nandrolone in the horse
Balssa, Frédéric,Fischer, Michael,Bonnaire, Yves
, p. 667 - 668 (2011)
5α-Estrane-3β,17α-diol is the major metabolite of nandrolone in horse urine. The presence of 5α-estrane-3β,17α- diol in female and gelding urines is prohibited by Racing Rules and its natural presence in male urine led regulation authorities to establish
Preparation method of [3-14C] marked 17alpha-estradiol
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Paragraph 0089; 0100-0101, (2019/06/07)
The invention belongs to the technical field of synthesis of compounds marked by radioisotope 14C, and provides a preparation method of [3-14C] marked 17alpha-estradiol. The preparation method includes the following steps that 17beta-acylated elollactone and 14C marked acetylchloride serve as starting materials, and a condensation reaction, a primary hydrolysis reaction, a Mitsunobu reaction, an aromatization reaction and a secondary hydrolysis reaction are carried out to obtain [3-14C] marked 17alpha-estradiol. The method has the advantages that the synthesis cost is low, the line is short and the product yield is high. Besides, the preparation method is easy to operate and suitable for large-scale production.
