1312809-32-7Relevant academic research and scientific papers
Studies on synthesis of a novel, broad-spectrum antitumor compound 2-(1-hydroxy-4-oxo-cyclohexa-2, 5-dienyl)-pyran-4-one
Wang, Xiaohua,Yang, Liu,Xue, Pingping,Ruan, Jinlan
, p. 39 - 42 (2017/03/08)
Based on the previous studies, used protoapigenone as a model, we adopted chemical synthesis methods to develop the new compounds. It was specifically named as 2-(1-hydroxy-4-oxo-2, 5-cyclohexadien-1-yl)-4H-Pyran-4-one, including a core group: 1-hydroxycy
A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: The disclosure of a new antitumor pharmacophore in protoapigenone 1
Yuan, Qianying,Liu, Ziwei,Xiong, Chaomei,Wu, Liqian,Wang, Jianping,Ruan, Jinlan
scheme or table, p. 3427 - 3430 (2011/07/07)
The synthesis of a new compound 9 containing the 4-hydroxy-2,5- cyclohexadien-1-one system, a key elements toward elucidation of the protoapigenone 1 antitumor pharmacophore, was described. The compound showed potent in vitro antitumor potency with low mi
