82891-99-4

Basic information

• Product Name: 2-(2-Nitroethyl)-[1,3]dioxolane
• Synonyms: 3-NITROPROPIONALDEHYDE ETHYLENE GLYCOL ACETAL;2-(2-NITROETHYL)-1,3-DIOXOLANE;1,3-Dioxolane, 2-(2-nitroethyl)-;2-(2-NITROETHYL)-1,3-DIOXOLANE FOR SYNTH
• CAS NO: 82891-99-4
• Molecular Formula: C₅H₉NO₄
• Molecular Weight: 147.13
• Mol File: 82891-99-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 68 °C(Press: 0.25 Torr)
• Appearance: White powder
• Density: 1.214±0.06 g/cm3(Predicted)
• Storage Temp.: Store below +30°C.
• PKA: 8.47±0.58(Predicted)
• CAS DataBase Reference: 2-(2-Nitroethyl)-[1,3]dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Nitroethyl)-[1,3]dioxolane(82891-99-4)
• EPA Substance Registry System: 2-(2-Nitroethyl)-[1,3]dioxolane(82891-99-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 82891-99-4(Hazardous Substances Data)

Usage

General Description

2-(2-Nitroethyl)-[1,3]dioxolane, also known as NED or NENAD, is a chemical compound with the molecular formula C5H9NO4. It is a colorless, flammable liquid with a slightly sweet odor. NED is used as a solvent and a reagent in various chemical reactions, particularly in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic compounds. NED is classified as a hazardous substance due to its flammability and potential to cause skin and eye irritation. It is important to handle and store NED carefully, following proper safety precautions to prevent accidents and exposure.

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 58657-26-4 3-nitropropionaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 2397-79-7 2-phenyl-4H-pyran-4-one 
• 467221-37-0 (Z)-3-Amino-4-[1,3]dioxolan-2-yl-1-phenyl-but-2-en-1-one 
• 467221-40-5 (Z)-3-Amino-1-(4-bromo-phenyl)-4-[1,3]dioxolan-2-yl-but-2-en-1-one 
• 467221-39-2 (Z)-3-Amino-4-[1,3]dioxolan-2-yl-1-(4-methoxy-phenyl)-but-2-en-1-one 
• 467221-38-1 4-((Z)-3-Amino-4-[1,3]dioxolan-2-yl-but-2-enoyl)-benzoic acid methyl ester 
• 1312809-32-7 C₁₄H₁₇NO₄ 
• 956316-86-2 benzyl 2-(4-((1,3-dioxolan-2-yl)methyl)-5-(4-fluorophenyl)-1-isopropyl-1H-pyrazol-3-yl)ethylcarbamate 
• 1312809-31-6 2-(1-hydroxy-4-oxo-cyclohexa-2,5-dienyl)-pyran-4-one 
• 117016-27-0 2-(4-hydroxyphenyl)-4H-pyran-4-one 
• 96202-73-2 (Z)-1-(1,3-dioxolan-2-yl)-2-nitronon-6-en-3-one p-toluenesulfonylhydrazone 
• 96202-74-3 (Z)-1-(1,3-dioxolan-2-yl)-non-6-en-3-one p-toluenesulfonylhydrazone 
• 94480-27-0 (5S)-5-<(phenylmethoxy)methyl>-3-<(1,3-dioxolan-2-yl)methyl>-4,5-dihydroisoxazole 
• 94480-28-1 (S)-5-Benzyloxy-1-[1,3]dioxolan-2-yl-4-hydroxy-pentan-2-one 
• 94371-03-6 5-Benzyloxy-1-[1,3]dioxolan-2-yl-4-hydroxy-pentan-2-one 

Relevant articles and documents

NOVEL COMPOUNDS AS INHIBITORS OF DNA METHYLTRANSFERASES

It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein A, R1, R2, and R3 are as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation.

Henry reaction of fluorinated nitro compounds

The Henry (nitroaldol) reaction of fluorinated nitro compounds with various aromatic aldehydes and a fluorinated aliphatic aldehyde to give β-fluoro-β-nitroalcohols which bearing a fluorinated quaternary carbon center was reported. The relative configuration of the major diastereoisomer of 2-fluoro-2-nitro-1-(4-nitrophenyl)-3-phenylpropanol (5bf) was determined by X-ray single crystal analysis.

METHODS FOR THE PREPARATION OF PYRAZOLE-CONTAINING COMPOUNDS

The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity.