1313040-16-2

Upstream product

• 1692-15-5 4-pyridylboronic acid 
• 202865-68-7 3-bromo-4-fluoro-benzylamine hydrochloride 
• 1535-75-7 2-trifluoromethoxy aniline 
• 1313041-44-9 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxyethyl)-7-trifluoromethoxy-1 H-indole-3-carbonyl]-piperidin-4-yl}benzyl)acetamide 
• 1313041-43-8 1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid 
• 1313041-42-7 2,2,2-trifluoro-1-[1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]ethan-1-one 
• 1313013-38-5 1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indole 
• 1208977-19-8 2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride 
• 1067427-53-5 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride 
• 259137-83-2 (2-Trifluoromethoxy-phenyl)-carbamic acid ethyl ester 
• 396075-93-7 (2-iodo-6-trifluoromethoxy-phenyl)-carbamic acid ethyl ester 
• 396075-92-6 (2-Trifluoromethoxy-6-trimethylsilanylethynyl-phenyl)-carbamic acid ethyl ester 
• 396075-91-5 7-trifluoromethoxy-1H-indole 

Downstream Products

• 1313040-15-1 [4-(5-aminomethyl-2-fluorophenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-7-trifluoromethoxy-1H-indol-3-yl]methanone hydrochloride 

Relevant academic research and scientific papers

INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).