131316-88-6

Basic information

• Product Name: Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester
• CAS NO: 131316-88-6
• Molecular Weight: 888.062
• Mol File: 131316-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester(131316-88-6)
• EPA Substance Registry System: Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester(131316-88-6)

Safety Data

• Hazardous Substances Data: 131316-88-6(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 129681-71-6 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine 

Relevant articles and documents

Tetraethylene glycol-derived spacer for oligonucleotide synthesis

3,6,9-Trioxaundecane-1,11-diisocyanate (6) was synthesised from tetraethylene glycol in 5 steps and 48 % overall yield. Spacer 6 was monofunctionalised with the fully protected adenosyl-3'-O-succinate derivative 7 and linked to aminomethyl polystyrene (50 % crosslinked with divinylbenzene) affording a solid support suitable for oligoribonucleotide synthesis (loading: ~20 μmol/g). The HPLC analysis of a crude oligoribonucleotide synthesis and the isolated yield of purified oligomer show that this spacer compares well to hexamethylene diamine.