131319-94-3

Basic information

• Product Name: (-)-(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone
• CAS NO: 131319-94-3
• Molecular Weight: 142.198
• Mol File: 131319-94-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone(131319-94-3)
• EPA Substance Registry System: (-)-(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone(131319-94-3)

Safety Data

• Hazardous Substances Data: 131319-94-3(Hazardous Substances Data)

Upstream product

• 123196-48-5 (+/-)-2,2-Dimethyl-4-tetrahydropyranyloxy-1-cyclohexanone 
• 123214-39-1 (+/-)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone 
• 76451-81-5 (+/-)-2,2-Dimethyl-4,4-ethylenedioxy-1-cyclohexanol 
• 131206-75-2 3,3-Dimethyl-4,4-ethylenedioxy-1-cyclohexanone 
• 1193-47-1 2,2-dimethyl-cyclohexanone 

Downstream Products

• 76686-09-4 (+)-(R)-4-Hydroxy-2,6,6-trimethyl-2-cyclohexen-1-one 
• 41703-33-7 (S)-2,2,6-Trimethyl-4-(tetrahydro-pyran-2-yloxy)-cyclohexanone 
• 131319-96-5 (+)-(R)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone 
• 123196-48-5 (S)-2,2-Dimethyl-4-(tetrahydro-pyran-2-yloxy)-cyclohexanone 

Relevant articles and documents

Enzymatic Preparation of Chiral 4-Hydroxy-2,2-dimethyl-1-cyclohexanone as a Chiral Building Block

(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone (1a) was prepared by two enzymatic methods. 1,4-Cyclohexanediol was converted to monoacetal (11) via (+/-)-1a.Enzymatic reduction of 11 by baker's yeast gave (S)-1 of almost 100 percent e.e.Direct hydroxylation of 2,2-dimethyl-1-cyclohexanone (14) by P-450 camphor monooxygenase of the cloned genes of Pseudomonas putida PpG1 gave (S)-1a of almost 100 percent e.e., too.According to Mitsunobu's method, SN-2 inversion of (S)-1 gave (R)-1.