76451-81-5

Upstream product

• 131206-75-2 3,3-Dimethyl-4,4-ethylenedioxy-1-cyclohexanone 

Downstream Products

• 69153-89-5 (4S)-2,2-dimethyl-4-deuteriocyclohexanone 
• 123196-48-5 (S)-2,2-Dimethyl-4-(tetrahydro-pyran-2-yloxy)-cyclohexanone 
• 131319-94-3 (-)-(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone 
• 131319-96-5 (+)-(R)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone 
• 41703-33-7 (S)-2,2,6-Trimethyl-4-(tetrahydro-pyran-2-yloxy)-cyclohexanone 
• 76686-09-4 (+)-(R)-4-Hydroxy-2,6,6-trimethyl-2-cyclohexen-1-one 

Relevant academic research and scientific papers

Enzymatic Preparation of Chiral 4-Hydroxy-2,2-dimethyl-1-cyclohexanone as a Chiral Building Block

(S)-4-Hydroxy-2,2-dimethyl-1-cyclohexanone (1a) was prepared by two enzymatic methods. 1,4-Cyclohexanediol was converted to monoacetal (11) via (+/-)-1a.Enzymatic reduction of 11 by baker's yeast gave (S)-1 of almost 100 percent e.e.Direct hydroxylation of 2,2-dimethyl-1-cyclohexanone (14) by P-450 camphor monooxygenase of the cloned genes of Pseudomonas putida PpG1 gave (S)-1a of almost 100 percent e.e., too.According to Mitsunobu's method, SN-2 inversion of (S)-1 gave (R)-1.