13132-12-2

Upstream product

• 42239-63-4 2-aminophenyl-(thien-2-yl)methanone 
• 930-96-1 3-bromo-2-thiophenecarboxaldehyde 
• 583-55-1 1-Bromo-2-iodobenzene 
• 1438251-52-5 (3-chlorothiophen-2-yl)(phenyl)methanone 

Downstream Products

• 78515-63-6 8H-Indeno<2,1-b>thiophen-8-one Triphenylphosphazine 
• 1448899-39-5 2-(4-(diphenylamino)phenyl)-8H-indeno[2,1-b]thiophen-8-one 
• 1448899-46-4 2-(5-(N,N-diphenylamino)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-one 
• 1448899-48-6 2-(5-(bis(4-methoxyphenyl)amino)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-one 
• 1448899-50-0 2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-one 
• 1448899-34-0 2-(2-(5-(diphenylamino)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-ylidene)malononitrile 
• 1448899-35-1 2-(2-(5-(bis(4-methoxyphenyl)amino)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-ylidene)malononitrile 
• 1448899-36-2 2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-8H-indeno[2,1-b]thiophen-8-ylidene)malononitrile 
• 1394850-40-8 2-(2-(4-(diphenylamino)phenyl)-8H-indeno[2,1-b]thiophen-8-ylidene)malononitrile 
• 1098260-41-3 8-phenyl-8H-indeno[2,1-b]thiophen-8-ol 

Relevant academic research and scientific papers

Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols

A palladium-catalyzed synthesis method of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo the reaction smoothly in the presence of Pd(OAc)2, affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies reveal that the reaction might be triggered by oxidation of alcohol followed by intramolecular reductive coupling.

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation

The efficiency of the deprotocupration-aroylation of 2-chloropyridine using lithiocuprates prepared from CuX (X=Cl, Br) and LiTMP (TMP=2,2,6,6- tetramethylpiperidido, 2 equiv) was investigated. CuCl was identified as a more suitable copper source than CuBr for this purpose. Different diaryl ketones bearing a halogen at the 2 position of one of the aryl groups were synthesized in this way from azines and thiophenes. These were then involved in palladium-catalyzed ring closure: substrates underwent expected CH-activation-type arylation to afford fluorenone-type compounds, and were also subjected to cyclization reactions leading to xanthones, notably in the presence of oxygen-containing substituents or reagents.