42239-63-4

Upstream product

• 50817-56-6 [2]thienyl-[2-(toluene-4-sulfonylamino)-phenyl]-ketone 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 118-48-9 isatoic anhydride 
• 1003-09-4 2-bromothiophene 
• 1885-29-6 anthranilic acid nitrile 
• 79419-74-2 3-hydroxy-3-(thiophen-2-yl)indolin-2-one 
• 1313215-29-0 2-((2-azidophenyl)ethynyl)thiophene 
• 118-92-3 anthranilic acid 
• 188290-36-0 thiophene 
• 55968-16-6 2-(2-thienyl)indole 
• 62-53-3 aniline 
• 103-84-4 Acetanilid 
• 141748-64-3 N-(2-(thiophene-2-carbonyl)phenyl)acetamide 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 

Downstream Products

• 171725-23-8 [2-(N-Cbz-glycylamino)phenyl]thienyl-2-ylketone 
• 34836-73-2 2,2,2-trichloro-N-[4-chloro-2-(2-thienylcarbonyl)phenyl]acetamide 
• 84671-22-7 2-(2'-[N-(3-chloro-2-hydroxylpropyl)-amino]-benzoyl)-thiophene 
• 745741-83-7 1-Methyl-2-[(furan-2-carbonyl)-aminomethyl]-5-(2'-thienyl)-1H-2,3-dihydro-1,4-benzodiazepine 
• 1610460-80-4 3-benzyl-1-methyl-3-(thiophen-2-yl)indolin-2-one 
• 817209-02-2 2-(1-(thiophen-2-yl)vinyl)aniline 
• 42239-38-3 2-(2-aminobenzyl)-thiophene 
• 6933-33-1 (2-iodophenyl)(thiophen-2-yl)methanone 
• 1388038-78-5 2-(phenylethynyl)-3-(thiophen-2-yl)-1-tosyl-1H-indole 
• 1315477-51-0 N-(2-(1-hydroxy-1-(thiophen-2-yl)prop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide 
• 1356841-39-8 NH₂C₆H₄CH(CH₃)C₄H₃S 
• 171724-68-8 [2-(N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)ureidomethylcarbonyl]amino}phenyl)thienyl-2-yl]ketone 
• 171725-26-1 (2-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbamoyl}phenyl)thienyl-2-ylketone 

Relevant academic research and scientific papers

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents

Two new hypervalent iodine reagents containing furan and thiophene moieties in addition to a carbonyl group in the vicinity of the iodine atom were synthesised and characterised. The X-ray analysis of both compounds revealed a strong intramolecular contact between the carbonyl oxygen and the hypervalent iodine atom with tosylate as a counter ion. The two reagents showed a broad range of synthetic applications and proved to be versatile oxidizing agents.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid

Disclosed is a method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid. The method comprises the steps that with 2-arylsulfonamido aromatic carboxylic acid shown in the description as a raw material and triphenylphosphine as a deoxidizer, under the illumination of blue light, in a 1,4-dioxane solution, under an argon atmosphere, in the presence of the dipotassium hydrogenphosphate, with [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst, the ortho-amino aromatic ketone compound is obtained; the structure of the photocatalyst [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 is shown in thedescription.

Cu(I)-Catalyzed Coupling and Cycloisomerization of Diazo Compounds with Terminal Yne-Alkylidenecyclopropanes: Synthesis of Functionalized Cyclopenta[ b]naphthalene Derivatives

A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[b]naphthalene derivatives in moderate to excellent yields under mild conditions.

Cascade Amination/Cyclization/Aromatization Process for the Rapid Construction of [2,3-c]Dihydrocarbazoles and [2,3-c]Carbazoles

An intramolecular cascade amination/cyclization/aromatization reaction of functionalized alkylidenecyclopropanes has been developed in the presence of silver acetate, affording a variety of [2,3-c]dihydrocarbazoles and [2,3-c]carbazoles in moderate to excellent yields. The mechanistic investigations revealed that this cascade reaction proceeds through a radical initiated process. Moreover, further transformations for the synthesis of eustifoline-D and an OLED exhibit a potential synthetic utility of this method.

2-Arylindoles: A new entry to transition metal-free synthesis of 2-aminobenzophenones

Various 2-aminobenzophenones were synthesized from readily available 2-arylindoles in DMSO under O2 balloon atmosphere. The synthesis was carried out without the aid of a transition metal catalyst or moisture-sensitive organometallic reagents from 2-arylindoles.

A one-pot process for palladium catalyzed direct C-H acylation of anilines in water using a removable ortho directing group

A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.

[2-[(Nitropyridinyl)amino]phenyl]arymethanones

[2-[(Nitropyridinyl)amino]phenyl]arylmethanones as chemical intermediates and/or having antidepressant activity having the formula: STR1 wherein: B is carbonyl, thioxomethyl, ketal or thioketal, R is hydrogen or -alk1 -Q, Q is hydrogen, --NR1 R2 or halogen are disclosed in a process for preparing pyrido[1,4]benzodiazepines.