131326-15-3

Basic information

• Product Name: L-phenylalanine 4-chlorobutyl ester hydrochloride
• Synonyms: L-phenylalanine 4-chlorobutyl ester hydrochloride
• CAS NO: 131326-15-3
• Molecular Weight: 292.205
• Mol File: 131326-15-3.mol

Chemical Properties

• CAS DataBase Reference: L-phenylalanine 4-chlorobutyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-phenylalanine 4-chlorobutyl ester hydrochloride(131326-15-3)
• EPA Substance Registry System: L-phenylalanine 4-chlorobutyl ester hydrochloride(131326-15-3)

Safety Data

• Hazardous Substances Data: 131326-15-3(Hazardous Substances Data)

Upstream product

• 928-51-8 4-Chloro-1-butanol 
• 63-91-2 L-phenylalanine 

Downstream Products

• 4530-37-4 N-t-butyloxycarbonylglycyl-L-phenylalanine 
• 76378-71-7 N-tritylglycyl-L-phenylalanine 
• 1170-76-9 Z-Gly-(L)-Phe 
• 131326-20-0 N-benzyloxycarbonylglycyl-L-phenylalanine 4-chlorobutyl ester 
• 131326-22-2 N-tritylglycyl-L-phenylalanine 4-chlorobutyl ester 
• 131326-21-1 N-tert-butoxycarbonylglycyl-L-phenylalanine 4-chlorobutyl ester 

Relevant articles and documents

USE OF 4-CHLOROBUTYL ESTERS IN PEPTIDE SYNTHESIS

Ho and Wong synthesised 4-chlorobutyl esters of simple carboxylic acids and removed the ester group by the action of sodium sulfide under reflux conditions.We describe here the synthesis of the 4-chlorobutyl esters of glycine and L-phenylalanine and its use in the synthesis of six new N-protected dipeptides 4-chlorobutyl esters (XHNCH2CO-HNCHRCO2(CH2)4Cl; R = H, CH2Ph; X = Z, Boc, Trt).The selective removal of the 4-chlorobutyl group can be achieved by the action of the sulfide anion in aqueous acetonitrile (room temperature, 1.5 to 5 h).The conditions are milder than those described, but similar to the conditions used with the dipeptides 2-bromoethyl esters.The N-protected dipeptides were isolated in 50 to 80percent yield.