131326-49-3Relevant academic research and scientific papers
Synthesis of serine/alanine conjugated 3′,5′-TpT
Qin, Zhi-Hui,Lin, Chang-Xue,Ju, Yong,Zhao, Yu-Fen
, p. 63 - 69 (2003)
Serine and alanine phosphoramidates conjugates of 3′,5′-TpT 4, 5 were synthesized. The corresponding serine phosphoamidate possesses some unique properties due to the presence of the side chain hydroxyl group.
An efficient oxidizing reagent for the synthesis of mixed backbone oligonucleotides via the H-phosphonate approach
Mohe, Nikhil U.,Padiya, Kamlesh J.,Salunkhe, Manikrao M.
, p. 1419 - 1431 (2003)
The mixture of carbon tetrachloride, N-methyl morpholine (NMM), pyridine and water in acetonitrile has been exploited for the oxidation of dinucleoside H-phosphonate diesters to the corresponding phosphates. The system is found to be inert to the phosphoramidate (P-N) and the phosphorothioate (P-S) linkages and has successfully been applied to the solid phase synthesis of mixed-backbone oligonucleotides (MBOs).
