1313370-94-3

Basic information

• Product Name: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate
• Synonyms: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate
• CAS NO: 1313370-94-3
• Molecular Weight: 232.282
• Mol File: 1313370-94-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate(1313370-94-3)
• EPA Substance Registry System: methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate(1313370-94-3)

Safety Data

• Hazardous Substances Data: 1313370-94-3(Hazardous Substances Data)

Upstream product

• 32857-63-9 4-t-butylphenylacetic acid 
• 3549-23-3 methyl 2-(4-tert-butylphenyl)acetate 

Downstream Products

• 1613403-67-0 (2E,4E)-methyl 2-(4-(tert-butyl)phenyl)-5-phenylpenta-2,4-dienoate 
• 1034854-37-9 methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate 
• 1394823-52-9 methyl 2-((2,2-dimethoxyethyl)amino)-2-(4-(tert-butyl)phenyl)acetate 

Relevant articles and documents

Silver-mediated direct trifluoromethoxylation of α-diazo esters: Via the -OCF3 anion

Silver-mediated direct trifluoromethoxylation of α-diazo esters and ketosteroid was disclosed. The reactions of alkyl α-diazo arylacetates with AgOCF3 or CF3SO2OCF3/AgF at -30 to 10 °C under a N2 atmosphere provided α-trifluoromethoxyl arylacetates in up to 90% yield, while alkyl α-diazo vinylacetates reacting with CF3SO2OCF3/AgF or AgOCF3 afforded γ-trifluoromethoxyl α,β-unsaturated esters in up to 94% yield. The α-diazo ketosteroid was also trifluoromethoxylated under the standard reaction conditions. This protocol allows for an effective and convenient access to a large number of synthetic building blocks, which are promising in the development of new functional OCF3-molecules.

B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes

Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.

Blue Light-Emitting Diode-Mediated in Situ Generation of Pyridinium and Isoquinolinium Ylides from Aryl Diazoesters: Their Application in the Synthesis of Diverse Dihydroindolizine

Blue light-emitting diode-mediated environmentally sustainable three component reactions among pyridine/isoquinoline 1/2, aryl diazoesters 3, and acrylic ester/3-alkenyl oxindoles 5/6 provide various dihydroindolizines 7 to 9 in excellent yield. The principle of the strategy is photolytic generation of nitrogen ylides from N-heteroarenes and aryl diazoesters and their subsequent [3 + 2] cycloaddition reaction with dipolarophiles. Detailed mechanistic analysis of the transformation through control experiments establishes this strategy as the foundation for the photolytic multicomponent reaction.