1034854-37-9

Basic information

• Product Name: methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate
• Synonyms: methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate
• CAS NO: 1034854-37-9
• Molecular Weight: 220.268
• Mol File: 1034854-37-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate(1034854-37-9)
• EPA Substance Registry System: methyl 2-(4-(tert-butyl)phenyl)-2-oxoacetate(1034854-37-9)

Safety Data

• Hazardous Substances Data: 1034854-37-9(Hazardous Substances Data)

Upstream product

• 7099-90-3 2-(4-(tert-butyl)phenyl)-2-oxoacetic acid 
• 74-88-4 methyl iodide 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 68185-96-6 (4-(tert-butyl)phenyl)(trimethylsilyl)methanone 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 1313370-94-3 methyl 2-(4-trifluoromethylphenyl)-2-diazoacetate 
• 3549-23-3 methyl 2-(4-tert-butylphenyl)acetate 
• 943-27-1 4'-t-butylacetophenone 
• 67-56-1 methanol 
• 772-38-3 4-tert-Butylphenylacetylene 
• 553-90-2 Dimethyl oxalate 
• 3972-65-4 1-bromo-4-tert-butylbenzene 

Downstream Products

• 1616777-65-1 methyl 2-(4-(tert-butyl)phenyl)-2-hydroxy-3-(2-phenyloxazol-5-yl)propanoate 
• 1034852-94-2 methyl 2-(4-tert-butylphenyl)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)acetate 

Relevant articles and documents

CuO-catalyzed oxidation of aryl acetates with aqueous tert-butyl hydroperoxide for the synthesis of α-ketoesters

A practical method to access α-ketoesters from readily available aryl acetates is developed. In this approach, aqueous tert-butyl hydroperoxide and CuO are employed. No additional solvents are required and it was found that the peroxide side products in the reaction can be decomposed by pyridine.

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Preparation method of alpha-ketoester compound

The invention discloses a preparation method of an alpha-ketone ester compound. The method specifically comprises the following operation steps: adding raw materials alpha-diazo ester and an organic photocatalyst into a reaction flask, then adding an organic solvent, and reacting for 2-12 hours in air at room temperature under the irradiation of a visible light lamp; after the reaction is monitored by thin-layer chromatography (TLC), stopping the reaction, and extracting a reaction solution by using ethyl acetate; concentrating the extracting solution under reduced pressure to obtain a crude product, and performing column chromatography separation on the crude product to obtain the alpha-diazonium ester compound. According to the preparation method, clean visible light is used as reaction energy, cheap organic dye is used as a photocatalyst, air is used as a green oxidizing agent and an oxygen source, and the preparation method has the advantages of simplicity and convenience in operation, no metal residue and mild reaction conditions.