245-49-8Relevant academic research and scientific papers
Hypervalent iodine(III) promoted direct synthesis of imidazo[1,2-a] pyrimidines
Qian, Guangyin,Liu, Bingxin,Tan, Qitao,Zhang, Siwen,Xu, Bin
, p. 4837 - 4843 (2014/08/05)
An efficient and mild synthesis of imidazo[1,2-a]pyrimidine derivatives has been developed from readily available pyrimidyl arylamines or enamines through a hypervalent iodine-promoted intramolecular C-H bond cycloamination reaction. This protocol allows for the facile construction of biologically active bicyclic imidazo[1,2-a]pyrimidine skeletons as well as other imidazo[1,2-a]-type fused heterocycles.
Synthesis of pyrido[1,2-a]benzimidazoles by photo-stimulated C-N bond formation via SRN1 reactions
Barolo, Silvia M.,Wang, You,Rossi, Roberto A.,Cuny, Gregory D.
, p. 5487 - 5494 (2013/06/27)
The photo-stimulated cyclization of 2-(2-halophenylamino)pyridines in liquid ammonia afforded pyrido[1,2-a]benzimidazoles via SRN1 mediated C-N bond forming reactions in moderate to excellent yields (58-94%). This general synthetic strategy was also extended to a 2-(2-bromophenylamino)pyrazine to give pyrazino[1,2-a]benzimidazole. Attempts to employ this reaction using N-(2-chlorophenyl)-3-isoquinolinamine, however, resulted in C-C bond formation generating 7H-indolo[2,3-c]isoquinoline.
Regiospecific synthesis of 1, 2-disubstituted (hetero)aryl fused imidazoles with tunable fluorescent emission
Zhao, Dongbing,Hu, Junyi,Wu, Ningjie,Huang, Xiaolei,Qin, Xurong,Lan, Jingbo,You, Jingsong
supporting information; experimental part, p. 6516 - 6519 (2012/02/02)
A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1, 2 disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaf
Synthesis of 5H-pyrazino[2,3-b]indoles from indole-2,3-dione derivatives
Bergman, Jan,Vallberg, Hans
, p. 742 - 752 (2007/10/03)
Reaction of N-acetylindol-2,3-diones with ethylenediamines gave the dihydropyrazinones 11, which could, after dehydrogenation and deacetylation, be transformed to the corresponding 5H-pyrazino[2,3-e]indoles 5. N,N-Dimethylaminoethylation of the anion of 5
