1313429-34-3

Upstream product

• 1616-70-2 2-methyl-3-(3-methoxyphenyl)valeric acid 
• 1616-63-3 3-hydroxy-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 1404478-78-9 3-(3-methoxy-phenyl)-2-methyl-pent-3-enoic acid ethyl ester 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 37951-49-8 1-(3-methoxyphenyl)propan-1-one 

Downstream Products

• 1313374-09-2 (αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide 
• 1313429-38-7 (S),(S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid dimethylamide 
• 1322723-88-5 (S,S)-3-(3-methoxy-phenyl)-2-methyl-pentan-1-ol 

Relevant academic research and scientific papers

Preparation method of 3-((1S,2S)-3-dimethylamino-1-ethyl-2-methylpropyl) phenol hydrochloride

The invention discloses a preparation method of 3-((1S,2S)-3-dimethylamino-1-ethyl-2-methylpropyl) phenol hydrochloride. 3-(3-methoxyphenyl)-2-methylvaleric acid is subjected to splitting of R-(+)-alpha-phenyl ethylamine and S-(-)-alpha-phenyl ethylamine, reductant complex reduction, acyl chloride reagent esterification, dimethyl amine hydrochloride substitution, de-methylation reagent de-methylation and trimethylchlorosilane salification to obtain the target product 3-(((1S, 2S)-3-dimethylamino-1-ethyl-2-methylpropyl) phenol hydrochloride. According to the method, the target compound is obtained by using a splitting method, chiral chromatographic column separation is avoided, the production is convenient, the yield is increased, and the cost is saved.

A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Disclosed herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R))-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, in high yield and purity. Also described are novel intermediates useful for preparing tapentadol or a pharmaceutically acceptable salt thereof.

PROCESS FOR THE PREPARATION OF 1-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES

A process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula (I) and its pharmaceutically acceptable salts thereof from cyano intermediate of formula (II), wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, -SOR2, SO2R2, -SO3H, -NO2, -NR2R2', -CONR2R2', carboxylic esters, sulfonate esters or phosphate esters, R2 and R2' can be same or different, and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl, -COR2", -P03(R2")2 wherein R2" can be selected from alkyl, aryl, aralkyl, heteroaryl and the like.

PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES

The present invention provides a process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula I, and its pharmaceutically acceptable salts thereof from intermediate of formula II, wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, SOR2, SO2R2, -SO3H, -NO2, -NR2R2', - CONR2R2 ', carboxylic esters, sulfonate esters or phosphate esters and the like; R ' can be selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, heteroaryl, and the like; or OR ' can be selected from -NR2R2 '; or R2 and R2 ' can be same or different and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl,-OR3, - COR3, -PO3(R3R4) wherein R3 and R4 can be same or different and can be selected from alkyl, aryl, aralkyl, heteroaryl and the like.