1616-70-2

Basic information

• Product Name: 2-methyl-3-(3-methoxyphenyl)valeric acid
• Synonyms: 2-methyl-3-(3-methoxyphenyl)valeric acid
• CAS NO: 1616-70-2
• Molecular Weight: 222.284
• Mol File: 1616-70-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-methyl-3-(3-methoxyphenyl)valeric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-(3-methoxyphenyl)valeric acid(1616-70-2)
• EPA Substance Registry System: 2-methyl-3-(3-methoxyphenyl)valeric acid(1616-70-2)

Safety Data

• Hazardous Substances Data: 1616-70-2(Hazardous Substances Data)

Upstream product

• 1322724-04-8 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanethioic acid S-phenyl ester 
• 1322724-02-6 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid dimethylamide 
• 1313429-20-7 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 52956-27-1 1-(3-methoxyphenyl)propanol 
• 2972-72-7 2-(3-methoxybenzylidene)malononitrile 
• 1313429-14-9 2-cyano-3-(3-methoxy-phenyl)-pentanoic acid ethyl ester 
• 1313429-27-4 3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 1313429-26-3 diethyl 1-(3-methoxyphenyl)propylmethylmalonate 
• 1313429-25-2 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid 
• 1313429-24-1 2-methyl-3-(3-methoxyphenyl)pentanenitrile 
• 1313429-23-0 3-(3-methoxy-phenyl)-2-methyl-2-(toluene-4-sulfonyl)-pentanenitrile 
• 1313429-22-9 3-(3-methoxy-phenyl)-2-methyl-2-(toluene-4-sulfonyl)-pentanoic acid ethyl ester 
• 1313429-21-8 2-[1-(3-methoxy-phenyl)-propyl]-2-methyl-malononitrile 
• 1313429-19-4 3-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-pentanenitrile 

Downstream Products

• 1313429-33-2 (R),(R)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid (R)-(+)-α-methylbenzylamine salt 
• 515114-52-0 (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol 
• 175591-09-0 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol hydrochloride 
• 175591-09-0 tapentadol hydrochloride 
• 175591-23-8 tapentadol 
• 175591-22-7 (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine 
• 1313429-24-1 2-methyl-3-(3-methoxyphenyl)pentanenitrile 
• 1313429-30-9 2-methyl-3-(3-methoxyphenyl)valeryl chloride 
• 1313374-17-2 N,N-dimethyl-2-methyl-3-(3-methoxyphenyl)valeramide 
• 1313429-32-1 (αR,βR)-β-ethyl-3-methoxy-α-methylbenzenepropanoic acid 
• 1313429-37-6 (R),(R)-3-(3-methoxy-phenyl)-2-methyl-pentanoyl chloride 
• 1313374-09-2 (αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide 
• 1322723-45-4 (+)-(2R,3S)-[3-(3-methoxyphenyl)-2-methylpentyl]-dimethylamine Hydrochloride 
• 1322723-56-7 3-(3-methoxy-phenyl)-2-methyl-pentan-1-ol 

Relevant articles and documents

Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof

The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.

PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES

The present invention provides a process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula I, and its pharmaceutically acceptable salts thereof from intermediate of formula II, wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, SOR2, SO2R2, -SO3H, -NO2, -NR2R2', - CONR2R2 ', carboxylic esters, sulfonate esters or phosphate esters and the like; R ' can be selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, heteroaryl, and the like; or OR ' can be selected from -NR2R2 '; or R2 and R2 ' can be same or different and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl,-OR3, - COR3, -PO3(R3R4) wherein R3 and R4 can be same or different and can be selected from alkyl, aryl, aralkyl, heteroaryl and the like.