13135-69-8

Usage

Uses

Used in Pharmaceutical Industry:
L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans(9CI) is used as a building block for the development of new drugs and medications. Its unique properties and trans configuration make it a valuable component in the creation of innovative pharmaceutical compounds.
Used in Chemical Synthesis:
L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans(9CI) is used as a key intermediate in the synthesis of various chemical compounds. Its specific structure and functional groups allow for the formation of new molecules with potential applications in different industries.
Used in Research:
L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans(9CI) is used as a research tool to study the properties and behavior of amino acid derivatives and their potential applications in various fields. Its unique trans configuration provides insights into the structural and functional aspects of similar compounds, contributing to the advancement of scientific knowledge.

Upstream product

• 67-56-1 methanol 
• 4252-82-8 (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid 
• 114358-11-1 (2S,4R)-2-methoxycarbonyl-4-hydroxypyrrolidine acetate 
• 51-35-4 4R-4-hydroxyproline 
• 50-00-0 formaldehyd 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 

Downstream Products

• 1269662-71-6 (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S,4R)-4-hydroxy-1-methyl-pyrrolidin-2-yl]propan-2-enoylamine 
• 1269662-81-8 (E)-3-[(2S,4R)-4-(tert-butyl(dimethyl)silyl)oxy-1-methylpyrrolidin-2-yl]-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]prop-2-enoylamine 

Relevant academic research and scientific papers

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present disclosure relates to 6-amino quinazoline or 3-cyano quinoline derivatives, preparation processes and pharmaceutical compositions containing them. Specifically, the present disclosure relates to novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by formula (I), or its tautomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salts thereof, or metabolite, metabolic precursor or prodrug thereof, and the uses for treatment especially for protein kinase inhibitors, in which each substitute group of general formula (I) is as defined in the specification.

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Unusual diastereoselection in the synthesis of nine-membered ring lactams and conformation-controlled transannular reactions to generate optically active indolizidinones

The aza-Claisen rearrangement of vinylpyrrolidines 1 yielded almost exclusively the trans-3,8-disubstituted nine-membered ring lactams 2 (TBS = tBuMe2Si), independent of whether cis or trans isomers were used as starting materials. The conforma

Synthese optisch aktiver neungliedriger Lactame durch zwitterionische Aza-Claisen-Reaktion

Stichworte: Aza-Claisen-Reaktion * Azoninone * Chiralitaetstransfer * Lactame

Beta-lactam compounds

A beta-lactam compound of the formula: STR1 or a pharmaceutically acceptable salt thereof, which is useful as an anti-microbial agent or an intermediate in the synthesis of anti-microbial agents.