1313712-90-1Relevant articles and documents
A Versatile Dynamic Mussel-Inspired Biointerface: From Specific Cell Behavior Modulation to Selective Cell Isolation
Liu, Lei,Tian, Xiaohua,Ma, Yue,Duan, Yuqing,Zhao, Xin,Pan, Guoqing
supporting information, p. 7878 - 7882 (2018/06/26)
Reported here is a novel dynamic biointerface based on reversible catechol-boronate chemistry. Biomimetically designed peptides with a catechol-containing sequence and a cell-binding sequence at each end were initially obtained. The mussel-inspired peptides were then reversibly bound to a phenylboronic acid (PBA) containing polymer-grafted substrate through sugar-responsive catechol-boronate interactions. The resultant biointerface is thus capable of dynamic presentation of the bioactivity (i.e. the cell-binding sequence) by virtue of changing sugar concentrations in the system (similar to human glycemic volatility). In addition, the sugar-responsive biointerface enables not only dynamic modulation of stem cell adhesion behaviors but also selective isolation of tumor cells. Considering the highly biomimetic nature and biological stimuli-responsiveness, this mussel-inspired dynamic biointerface holds great promise in both fundamental cell biology research and advanced medical applications.
A synthetic approach toward a self-regulated insulin delivery system
Matsumoto, Akira,Ishii, Takehiko,Nishida, Junko,Matsumoto, Hiroko,Kataoka, Kazunori,Miyahara, Yuji
supporting information; experimental part, p. 2124 - 2128 (2012/04/18)
Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a "skin layer" enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo- and hyperglycemia. Copyright
