1313881-69-4

Basic information

• Product Name: tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate
• Synonyms: tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate
• CAS NO: 1313881-69-4
• Molecular Weight: 532.645
• Mol File: 1313881-69-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate(1313881-69-4)
• EPA Substance Registry System: tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate(1313881-69-4)

Safety Data

• Hazardous Substances Data: 1313881-69-4(Hazardous Substances Data)

Upstream product

• 1259223-99-8 4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)benzoic acid 
• 1313883-39-4 tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-chloro-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 98-80-6 phenylboronic acid 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 1313883-38-3 tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 1439394-28-1 tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 1259224-00-4 [1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester 
• 1359656-25-9 tert-butyl (1-(4-nitrophenyl)cyclobutyl)carbamate 
• 1032350-06-3 tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate 
• 1032350-05-2 1-(4-bromophenyl)cyclobutanecarboxylic acid amide 
• 485828-58-8 1-(4- bromophenyl)cyclobutane-1-carbonitrile 
• 16532-79-9 4-Bromophenylacetonitrile 
• 202737-42-6 1-(4-nitrophenyl)cyclobutanecarboxylic acid 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 

Downstream Products

• 1313883-00-9 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine hydrochloride 
• 1313881-95-6 N-(1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)acetamide 

Relevant articles and documents

Compositions and Methods for Treating Proliferation Disorders

The present invention relates to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-(3-morpholinophenyl)-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine or N-(1-(3-(3-(4-(1-aminocyclobutyl)phenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl)phenyl)piperidin-4-yl)-N-methylacetamide. The methods of the present invention can also relate to methods of treating cell proliferative disorders, such as cancer or Proteus syndrome, by utilizing the above compounds in combination with ((R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine).

PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE

The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine: