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Usage

Uses

Used in Pharmaceutical Industry:
4-(2,2,2-Trifluoroethyl)aniline is used as an intermediate in the production of pharmaceuticals for its ability to contribute to the development of new drugs with enhanced properties. Its unique trifluoroethyl group can improve the pharmacokinetics and pharmacodynamics of the resulting compounds, leading to more effective medications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2,2,2-trifluoroethyl)aniline is utilized as a building block in the synthesis of various agrochemicals, such as pesticides and herbicides. Its incorporation can enhance the effectiveness of these products, providing better control over pests and weeds in agricultural settings.
Used in Dye Industry:
4-(2,2,2-Trifluoroethyl)aniline is employed as a key intermediate in the production of dyes, where its unique chemical structure can impart specific color characteristics and properties to the final dye products. This allows for the creation of a wide range of dyes with diverse applications in various industries.
Used in Organic Synthesis:
As a building block in organic synthesis, 4-(2,2,2-trifluoroethyl)aniline is used to construct a variety of organic compounds with different applications. Its trifluoroethyl group can be a valuable structural element in the synthesis of complex organic molecules, contributing to the development of new materials and compounds with specific functions.
Safety Considerations:
While 4-(2,2,2-trifluoroethyl)aniline is considered to have low toxicity, it is essential to handle and use it with caution. Prolonged or repeated exposure may cause irritation to the skin, eyes, and respiratory system. Appropriate safety measures should be taken to minimize potential health risks during its use in various applications.

Upstream product

• 3764-36-1 1-nitro-4-(2,2,2-trifluoroethyl)benzene 
• 7440-44-0 pyrographite 
• 7440-05-3 palladium 
• 62-53-3 aniline 
• 91-73-6 N,N-dibenzylaniline 

Downstream Products

• 1281860-82-9 N-(4-(2,2,2-trifuoroethyl)phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 

Relevant academic research and scientific papers

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Divergent synthesis of photoaffinity probe candidates by click reactions of azido-substituted aryltrifluoromethyldiazirines

Two types of azido-substituted aryltrifluoromethyldiazirine units have been designed and prepared for the divergent synthesis of photoaffinity probe (PAP) candidates. Using these azides, various aryltrifluoromethyldiazirine derivatives have been rendered easily synthesizable by several click reactions, as well as the Staudinger reduction affording the corresponding aniline. The triazole-conjugated aryltrifluoromethyldiazirine derivatives prepared in this study showed normal photoreactivity compared with those reported previously. These results indicate the utility of these azido-substituted aryltrifluoromethyldiazirine units for development of PAPs for target identification of bioactive compounds.

A facile synthesis of isomeric C -(2,2,2-trifluoroethyl)anilines

Three isomers of C-(2,2,2-trifluoroethyl)aniline were prepared on a multigram scale from readily available nitrophenylacetic acids in two steps. First, the carboxy groups of the latter were converted into the trifluoromethyl moieties by treatment with sul

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.

Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation

Pharmaceutical compositions are disclosed. They are useful for the treatment of medical conditions associated with the effects of glutamate, comprise as active principle, at least one compound of formula: STR1 or a salt thereof, in which either R1 represents polyfluoroalkoxy, 2,2,2-trifluoroethyl, pentafluoroethyl, tert-butyl, trimethylsilyl or trifluoromethylthio and R2 and R3 represent hydrogen, or R1 represents polyfluoroalkoxy, R2 represents hydrogen and R3 represents alkyl, amino, alkoxy, phenyl, phenylalkyl, dimethylamino or dialkylaminoakylthio, or R1 represents polyfluoroalkoxy, R2 represents amino and R3 represents hydrogen, with the exception of 6-trifluoromethoxy-2-benzothiazolamine.