13140-73-3

Basic information

• Product Name: 3'-Bromo-2-phenylacetoanilide
• Synonyms: 3'-Bromo-2-phenylacetoanilide;N-(3-Bromophenyl)benzeneacetamide
• CAS NO: 13140-73-3
• Molecular Formula: C₁₄H₁₂BrNO
• Molecular Weight: 290.17
• Mol File: 13140-73-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-Bromo-2-phenylacetoanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Bromo-2-phenylacetoanilide(13140-73-3)
• EPA Substance Registry System: 3'-Bromo-2-phenylacetoanilide(13140-73-3)

Safety Data

• Hazardous Substances Data: 13140-73-3(Hazardous Substances Data)

Upstream product

• 591-19-5 m-Bromoaniline 
• 103-80-0 phenylacetyl chloride 
• 109134-07-8 t-butyl<3-(trifluoromethyl)phenyl>-carbamate 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 37831-25-7 N-(3-bromophenyl)formamide 
• 108-88-3 toluene 

Downstream Products

• 1382354-13-3 2-(3-2-phenylacetamidophenylamino)benzamide 

Relevant articles and documents

Electronic properties of anticonvulsant amides. A C-13 nuclear magnetic resonance study of phenylacetanilides

-

Metal-free hydration of ynamides: Convenient approach to amides

The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Selective inhibitors of human sirtuin 2 (SIRT2), a deacetylase, are candidate therapeutic agents for neurodegenerative diseases such as Parkinson's disease and Huntington's disease as well as potential tools for elucidating the biological functions of SIRT2. On the basis of homology models of SIRT1 and SIRT2, we designed and prepared a series of 2-anilinobenzamide analogues. Enzyme assays using recombinant SIRT1 and SIRT2 revealed that 3'-phenethyloxy-2- anilinobenzamide analogues such as 33a and 33i are potent and selective SIRT2 inhibitors, showing more than 3.5-fold greater SIRT2-inhibitory activity and more than 35-fold greater SIRT2-selectivity compared with AGK2 (3), a previously reported SIRT2-selective inhibitor. Compound 33a also induced a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells, indicating selective inhibition of SIRT2 in the cells. These 3'-phenethyloxy-2-anilinobenzamide derivatives represent an entry into a new class of SIRT2-selective inhibitors.