1314079-79-2Relevant academic research and scientific papers
Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines
Low, Eddy,Kim, Bum,Francavilla, Charles,Shiau, Timothy P.,Turtle, Eric D.,O'Mahony, Donogh J.R.,Alvarez, Nichole,Houchin, Ashley,Xu, Ping,Zuck, Meghan,Celeri, Chris,Anderson, Mark B.,Najafi, Ramin,Jain, Rakesh K.
, p. 3682 - 3685 (2011/08/06)
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.
