1314136-00-9

Usage

Uses

Used in Pharmaceutical Development:
3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form essential carbon-carbon and carbon-heteroatom bonds, which are vital for creating bioactive molecules with potential therapeutic effects.
Used in Agrochemical Synthesis:
In the agrochemical industry, 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester is used as a building block for the development of new agrochemicals, leveraging its reactivity to form complex molecules with pesticidal or herbicidal properties.
Used in Materials Science:
3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester is employed as a component in the synthesis of advanced materials, where its unique reactivity and structural features contribute to the creation of materials with specific properties for various applications in science and technology.
Used in Organic Synthesis:
As a versatile reagent in organic synthesis, 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester is used for the formation of complex organic molecules, serving as a valuable building block in the creation of compounds with diverse applications across different industries.

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 1416157-63-5 (E)-1-(5-bromo-2-hydroxyphenyl)ethanone oxime 
• 66033-76-9 5-bromo-3-methyl-1,2-benzisoxazole 
• 73183-34-3 bis(pinacol)diborane 
• 92832-02-5 1-(5-bromo-2-hydroxyphenyl)ethanimine 

Relevant academic research and scientific papers

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Pyrimidine compounds and methods of making and using same

Disclosed herein are pyrimidinyl compounds that are contemplated to be modulators of cystic fibrosis transmembrane regulators (CFTR), and methods of making and using same. Also provided are pharmaceutical compositions and methods of treating disorders associated with cystic fibrosis transmembrane regulators, such as airway inflammation, cystic fibrosis, and the like.