1314140-45-8

Basic information

• Product Name: (2E)-1-(4-methoxyphenyl)-3-[methyl(phenyl)amino]prop-2-en-1-one
• Synonyms: (2E)-1-(4-methoxyphenyl)-3-[methyl(phenyl)amino]prop-2-en-1-one
• CAS NO: 1314140-45-8
• Molecular Weight: 267.327
• Mol File: 1314140-45-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2E)-1-(4-methoxyphenyl)-3-[methyl(phenyl)amino]prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-methoxyphenyl)-3-[methyl(phenyl)amino]prop-2-en-1-one(1314140-45-8)
• EPA Substance Registry System: (2E)-1-(4-methoxyphenyl)-3-[methyl(phenyl)amino]prop-2-en-1-one(1314140-45-8)

Safety Data

• Hazardous Substances Data: 1314140-45-8(Hazardous Substances Data)

Upstream product

• 31706-15-7 3-(4-methoxy-phenyl)-3-oxo-propionaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 
• 100-61-8 N-methylaniline 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1314140-71-0 C₂₂H₂₃NO₆ 
• 1314140-56-1 dimethyl 3-(4-methoxyphenyl)-5-[methyl(phenyl)amino]furan-2,2(5H)-dicarboxylate 
• 1314140-57-2 dimethyl 3-(4-methoxybenzoyl)-1-methylquinoline-4,4(1H)-dicarboxylate 

Relevant articles and documents

Highly Site-Selective Metal-Free C-H Acyloxylation of Stable Enamines

A highly site-selective acyloxylation of stable enamines with PhI(OAc)2 under metal-free conditions to afford (E)-vinyl acetate derivatives in good to excellent yields is described. Depending on the judicious choice of the solvent system, either the α- or β-site-selective product could be obtained with high selectivity. For the α-site-selective product, the rearranged amide compound is obtained as the major product. This reaction proceeds under mild reaction conditions (room temperature, metal-free, and open-flask) and features a broad substrate scope.

Synthesis of the naphthalenone, dihydroquinoline, and dihydrofuran derivatives

The reactions of enaminones with dimethyl diazomalonate were investigated in the presence of copper(II) acetylacetonate. From the reaction of (E)-3-[methyl(phenyl)amino]-1-phenylprop-2-en-1-one (6c), dimethyl 2-[methyl(phenyl)amino]-4-oxonaphthalene-1,1-(4H)-dicarboxylate, was unexpectedly obtained as the major product. Quinoline derivatives were formed as the major products in the case of N-methyl-p-anisidino and N-methyl-p-toluidino enaminones. The reactions of acetyl enaminones were also realized, and quinoline derivatives were isolated as the major products. 3H- and 5H-dihydrofurans were also formed as side products in these reactions. These results differ from those reported earlier on the reactions of tertiary enaminones with carbenes/metal carbenes.