1314534-00-3Relevant academic research and scientific papers
Feasible synthesis of the GPR40 antagonist by contructing 2-thiouracil ring VIA acid mediated cyclization
Zhao, Yongfeng,Liao, Jiayu
experimental part, p. 1145 - 1151 (2011/06/10)
GW1100 is an antagonist of GPR40 identified by high throughput screening recently. The feasible synthesis of GW1100 has been developed in mild conditions. The key step involves the cyclization of the 2-thiouracil heterocycle under acidic conditions at room temperature. The Japan Institute of Heterocyclic Chemistry.
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Boyd, Helen F.,Hammond, Beverley,Hickey, Deirdre M.B.,Ife, Robert J.,Leach, Colin A.,Lewis,Macphee, Colin H.,Milliner, Kevin J.,Pinto, Ivan L.,Smith, Stephen A.,Stansfield, Ian G.,Theobald, Colin J.,Whittaker, Caroline M.
, p. 701 - 704 (2007/10/03)
Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties
