1314539-20-2Relevant articles and documents
Synthesis and antibacterial activity of four natural chalcones and their derivatives
Li, Yuanyuan,Sun, Bingxia,Zhai, Jiadai,Fu, Lin,Zhang, Shuxin,Zhang, Jing,Liu, Hongliang,Xie, Wenhai,Deng, Hongkuan,Chen, Zhiwei,Sang, Feng
, (2019)
Four natural chalcones bearing hydroxyisoprenyl or prenyl groups, named Paratocarpin E (2), Xanthoangelol D (3), Angusticornin A (4) and Kanzonol C (5), were prepared by employing the Claisen-Schmidt condensation as the key step. In an attempt to investigate the effect of the hydroxyisoprenyl group on biological activity, two of their derivatives were also prepared for antibacterial activity research. The synthesized compounds were investigated for their expected antibacterial activities against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) as well as Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Paratocarpin E (2) was found to be the most potent against two Gram positive bacteria while the majority of the remaining compounds showed promising activity as well. However, all of the compounds were inactive against both Gram-negative bacteria.
Synthesis method and use of natural product Angusticornin A
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, (2019/11/21)
The invention discloses a synthesis method and use of a natural product that is Angusticornin A. The structure formula (I) of the natural product is shown in the description. The obtained natural product Angusticornin A has good inhibitory activity agains
Synthetic method and application of natural product Kanzonol C and derivatives thereof
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, (2019/12/02)
The invention discloses a synthetic method and application of a natural product Kanzonol C and derivatives thereof. The structural formula (I) and (II) are shown in the specification: compared with anatural product Kanzonol C, the obtained novel isopenten